Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway.
J Am Chem Soc
American Chemical Society (ACS)
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Gu, Z., Liu, T., Tang, J., Yang, Y., Song, H., Tuong, K., Fu, J., & et al. (2019). Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway.. J Am Chem Soc, 141 (15), 6122-6126. https://doi.org/10.1021/jacs.8b10904
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure-function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.
Macrophages, Animals, Mice, Ferric Compounds, Lipopolysaccharides, Signal Transduction, Macrophage Activation, Phenotype, Nanoparticles, RAW 264.7 Cells
The authors acknowledge the support from the Australian Research Council, Australian Microscopy and Microanalysis Research Facil- ity at the Centre for Microscopy and Microanalysis and the Aus- tralian National Fabrication Facility at the University of Queens- land. Z.Y.G acknowledges the Australia Research Training Pro- gram (RTP) Scholarship. Z.K.T. is supported by an Advance Queensland Research Fellowship.
External DOI: https://doi.org/10.1021/jacs.8b10904
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292753
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