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Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Sousa, Filipa L 
Parente, Daniel J 
Hessman, Jacob A 
Chazelle, Allen 
Teichmann, Sarah A 

Abstract

The AlloRep database (www.AlloRep.org) (Sousa et al., 2016) [1] compiles extensive sequence, mutagenesis, and structural information for the LacI/GalR family of transcription regulators. Sequence alignments are presented for >3000 proteins in 45 paralog subfamilies and as a subsampled alignment of the whole family. Phenotypic and biochemical data on almost 6000 mutants have been compiled from an exhaustive search of the literature; citations for these data are included herein. These data include information about oligomerization state, stability, DNA binding and allosteric regulation. Protein structural data for 65 proteins are presented as easily-accessible, residue-contact networks. Finally, this article includes example queries to enable the use of the AlloRep database. See the related article, "AlloRep: a repository of sequence, structural and mutagenesis data for the LacI/GalR transcription regulators" (Sousa et al., 2016) [1].

Description

Keywords

0601 Biochemistry and Cell Biology, Genetics, Generic Health Relevance

Journal Title

Data Brief

Conference Name

Journal ISSN

2352-3409
2352-3409

Volume Title

8

Publisher

Elsevier BV