Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt, Tom; Łapińska, Urszula; Kumita, Janet; Whiten, Daniel; Klenerman, David; Wilson, Mark R; Cohen, Samuel IA; Linse, Sara; Vendruscolo, Michele; Dobson, Christopher; Knowles, Tuomas; Arosio, Paolo

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Authors

Scheidt, Tom

Łapińska, Urszula

Kumita, Janet

Whiten, Daniel

Klenerman, David

Wilson, Mark R

Cohen, Samuel IA

Publication Date

2019-04-17

Journal Title

Science advances

ISSN

2375-2548

Volume

Issue

Pages

eaau3112

Language

eng

Type

Article

This Version

VoR

Physical Medium

Electronic-eCollection

Metadata

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Citation

Scheidt, T., Łapińska, U., Kumita, J., Whiten, D., Klenerman, D., Wilson, M. R., Cohen, S. I., et al. (2019). Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.. Science advances, 5 (4), eaau3112. https://doi.org/10.1126/sciadv.aau3112

Keywords

Humans, Alzheimer Disease, Peptide Fragments, Recombinant Proteins, Microfluidics, Protein Binding, Kinetics, Clusterin, Amyloid beta-Peptides, Protein Aggregates

Sponsorship

European Research Council (337969)

European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (766972)

Wellcome Trust (094425/Z/10/Z)

Identifiers

External DOI: https://doi.org/10.1126/sciadv.aau3112

This record's URL: https://www.repository.cam.ac.uk/handle/1810/293154

Rights

Attribution-NonCommercial 4.0 International

Licence URL: https://creativecommons.org/licenses/by-nc/4.0/

Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International