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The distribution of autistic traits across the autism spectrum: Evidence for discontinuous dimensional subpopulations underlying the autism continuum

Published version
Peer-reviewed

Type

Article

Change log

Authors

Abu-Akel, Ahmad 
Baron-Cohen, simon 
Heinke, Dietmar 

Abstract

BACKGROUND A considerable amount of research has discussed whether autism, and psychiatric/neurodevelopmental conditions in general are best described categorically or dimensionally. In recent years, finite mixture models have been increasingly applied to mixed populations of autistic and non-autistic individuals to answer this question. However, the use of such methods with mixed populations may not be appropriate for two reasons: First, subgroups within mixed populations are often skewed, and thus violate mixture models assumptions, which are based on weighted sum of Gaussian distributions. Second, these analyses have, to our knowledge, been solely applied to enriched samples, where the prevalence of the clinical condition within the study sample far exceeds epidemiological estimates. METHOD We employed a dual Weibull Mixture model to examine the distribution of the Autism Spectrum Quotient scores of a mixed sample of autistic and non-autistic adults (N = 4717; autism = 811), as well as of a derived sample (from the enriched sample; N = 3973; autism = 67) that reflects the current prevalence of autism within the general population. RESULTS In a mixed autistic and non-autistic population, our model provided a better description of the underlying structure of autistic traits than traditional finite Gaussian mixture models, and performed well when applied to a sample that reflected the prevalence of autism in the general population. The model yielded results, which are consistent with predictions of current theories advocating for the co-existence of a mixed categorical and dimensional architecture within the autism spectrum. CONCLUSION The results provide insight into the continuum nature of the distribution of autistic traits, support the complementary role of both categorical and dimensional approaches to autism spectrum condition, and underscore the importance of analysing samples that reflect the epidemiological prevalence of the condition. Owing to its flexibility to represent a wide variety of distributions, the Weibull distribution might be better suited for latent structure studies, within enriched and prevalence-true samples.

Description

Keywords

Adolescent, Adult, Aged, Autism Spectrum Disorder, Female, Humans, Male, Middle Aged, Models, Statistical, Population Dynamics, Prevalence, Young Adult

Journal Title

Molecular Autism

Conference Name

Journal ISSN

2040-2392
2040-2392

Volume Title

10

Publisher

BioMed Central
Sponsorship
Autism Research Trust (unknown)
Templeton World Charity Foundation (TWCF) (TWCF0138/AB89)
The project leading to this application has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 777394. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI This work was supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) East of England at Cambridgeshire and Peterborough NHS Foundation Trust, the Medical Research Council, the NIHR Cambridge Biomedical Research Centre, and the Autism Research Trust. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.