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dc.contributor.authorPattison, Luke Aen
dc.contributor.authorCallejo, Gerarden
dc.contributor.authorSt John Smith, Ewanen
dc.date.accessioned2019-06-03T23:30:06Z
dc.date.available2019-06-03T23:30:06Z
dc.date.issued2019-11en
dc.identifier.issn0962-8436
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293311
dc.description.abstractNociceptors, i.e. sensory neurones tuned to detect noxious stimuli, are found in numerous phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, e.g. heat, cold, pressure and chemicals, such as acid. Due to the ability of protons to have a profound effect on ionic homeostasis and damage macromolecular structures, it is no wonder that the ability to detect acid is conserved across many species. To detect changes in pH, nociceptors are equipped with an assortment of different acid sensors, some of which can detect mild changes in pH, such as the acid-sensing ion channels, proton-sensing G protein-coupled receptors and several two-pore potassium channels, whereas others, such as the transient receptor potential vanilloid 1 ion channel, require larger shifts in pH. This review will discuss the evolution of acid sensation and the different mechanisms by which nociceptors can detect acid.
dc.description.sponsorshipVersus Arthritis (RG21973) University of Cambridge BBSRC Doctoral Training Programme (BB/M011194/1)
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherThe Royal Society
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectNociceptorsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectPainen
dc.subjectBiological Evolutionen
dc.subjectNociceptionen
dc.subjectAcid Sensing Ion Channelsen
dc.titleEvolution of acid nociception: ion channels and receptors for detecting acid.en
dc.typeArticle
prism.issueIdentifier1785en
prism.publicationDate2019en
prism.publicationNamePhilosophical transactions of the Royal Society of London. Series B, Biological sciencesen
prism.startingPage20190291
prism.volume374en
dc.identifier.doi10.17863/CAM.40465
dcterms.dateAccepted2019-05-28en
rioxxterms.versionofrecord10.1098/rstb.2019.0291en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11en
dc.contributor.orcidPattison, Luke A [0000-0001-8571-3314]
dc.identifier.eissn1471-2970
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idArthritis Research UK (11600/21973)
pubs.funder-project-idBBSRC (BB/M011194/1)
cam.orpheus.successThu Jan 30 10:44:31 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2019-11-30


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