Evolution of acid nociception: ion channels and receptors for detecting acid.
St John Smith, Ewan
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
The Royal Society
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Pattison, L. A., Callejo, G., & St John Smith, E. (2019). Evolution of acid nociception: ion channels and receptors for detecting acid.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 374 (1785), 20190291. https://doi.org/10.1098/rstb.2019.0291
Nociceptors, i.e. sensory neurones tuned to detect noxious stimuli, are found in numerous phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, e.g. heat, cold, pressure and chemicals, such as acid. Due to the ability of protons to have a profound effect on ionic homeostasis and damage macromolecular structures, it is no wonder that the ability to detect acid is conserved across many species. To detect changes in pH, nociceptors are equipped with an assortment of different acid sensors, some of which can detect mild changes in pH, such as the acid-sensing ion channels, proton-sensing G protein-coupled receptors and several two-pore potassium channels, whereas others, such as the transient receptor potential vanilloid 1 ion channel, require larger shifts in pH. This review will discuss the evolution of acid sensation and the different mechanisms by which nociceptors can detect acid.
Nociceptors, Animals, Humans, Pain, Biological Evolution, Nociception, Acid Sensing Ion Channels
Versus Arthritis (RG21973) University of Cambridge BBSRC Doctoral Training Programme (BB/M011194/1)
Arthritis Research UK (11600/21973)
External DOI: https://doi.org/10.1098/rstb.2019.0291
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293311
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