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dc.contributor.authorBrzosko, Zuzannaen
dc.contributor.authorMierau, Susanna Ben
dc.contributor.authorPaulsen, Oleen
dc.date.accessioned2019-06-10T23:30:12Z
dc.date.available2019-06-10T23:30:12Z
dc.date.issued2019-08en
dc.identifier.issn0896-6273
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293509
dc.description.abstractSpike timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral learning and memory with rich computational properties. However, the relationship between the millisecond-precision spike timing required for STDP and the much slower time scales of behavioral learning is not well understood. Neuromodulation offers an attractive mechanism to connect these different time scales, and there is now strong experimental evidence that STDP is under neuromodulatory control by acetylcholine, monoamines and other signaling molecules. Here, we review neuromodulation of STDP, the underlying mechanisms, functional implications and possible involvement in brain disorders.
dc.description.sponsorshipBBSRC
dc.format.mediumPrinten
dc.languageengen
dc.publisherCell Press
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAstrocytesen
dc.subjectNeuronsen
dc.subjectPresynaptic Terminalsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectBrain Diseasesen
dc.subjectNeurodegenerative Diseasesen
dc.subjectSubstance-Related Disordersen
dc.subjectReceptors, Neurotransmitteren
dc.subjectNeurotransmitter Agentsen
dc.subjectBrain Mappingen
dc.subjectBehavioren
dc.subjectLearningen
dc.subjectObsessive-Compulsive Disorderen
dc.subjectSignal Transductionen
dc.subjectSpecies Specificityen
dc.subjectAction Potentialsen
dc.subjectNeuronal Plasticityen
dc.subjectModels, Neurologicalen
dc.subjectTime Factorsen
dc.subjectStrokeen
dc.subjectMolecular Targeted Therapyen
dc.subjectNeurodevelopmental Disordersen
dc.subjectMemory Consolidationen
dc.subjectReinforcement, Psychologyen
dc.titleNeuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.en
dc.typeArticle
prism.endingPage581
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameNeuronen
prism.startingPage563
prism.volume103en
dc.identifier.doi10.17863/CAM.40647
dcterms.dateAccepted2019-05-24en
rioxxterms.versionofrecord10.1016/j.neuron.2019.05.041en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08en
dc.contributor.orcidPaulsen, Ole [0000-0002-2258-5455]
dc.identifier.eissn1097-4199
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/N019008/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (700999)
pubs.funder-project-idBBSRC (BB/P019560/1)
pubs.funder-project-idBBSRC (BB/N00096X/1)
cam.orpheus.successThu Jan 30 10:43:48 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-08-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International