Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.
Mierau, Susanna B
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Brzosko, Z., Mierau, S. B., & Paulsen, O. (2019). Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.. Neuron, 103 (4), 563-581. https://doi.org/10.1016/j.neuron.2019.05.041
Spike timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral learning and memory with rich computational properties. However, the relationship between the millisecond-precision spike timing required for STDP and the much slower time scales of behavioral learning is not well understood. Neuromodulation offers an attractive mechanism to connect these different time scales, and there is now strong experimental evidence that STDP is under neuromodulatory control by acetylcholine, monoamines and other signaling molecules. Here, we review neuromodulation of STDP, the underlying mechanisms, functional implications and possible involvement in brain disorders.
Astrocytes, Neurons, Presynaptic Terminals, Animals, Humans, Brain Diseases, Neurodegenerative Diseases, Substance-Related Disorders, Receptors, Neurotransmitter, Neurotransmitter Agents, Brain Mapping, Behavior, Learning, Obsessive-Compulsive Disorder, Signal Transduction, Species Specificity, Action Potentials, Neuronal Plasticity, Models, Neurological, Time Factors, Stroke, Molecular Targeted Therapy, Neurodevelopmental Disorders, Memory Consolidation, Reinforcement, Psychology
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (700999)
External DOI: https://doi.org/10.1016/j.neuron.2019.05.041
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293509
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/