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dc.contributor.authorMartineau, Adrian Ren
dc.contributor.authorThummel, Kenneth Een
dc.contributor.authorWang, Zhicanen
dc.contributor.authorJolliffe, David Aen
dc.contributor.authorBoucher, Barbara Jen
dc.contributor.authorGriffin, Simonen
dc.contributor.authorForouhi, Nitaen
dc.contributor.authorHitman, Graham Aen
dc.date.accessioned2019-06-12T23:30:13Z
dc.date.available2019-06-12T23:30:13Z
dc.date.issued2019-12en
dc.identifier.issn0021-972X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293580
dc.description.abstractABSTRACT Context: Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism. Objective: To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3. Methods: We measured baseline and 4-month serum concentrations of vitamin D3, 25-hydroxyvitamin D3 (25[OH]D3), 25-hydroxyvitamin D2, 24R,25-dihydroxyvitamin D3 (24R,25[OH]2D3), 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3) and 4β,25-dihydroxyvitamin D3 (4β,25[OH]2D3) in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D2 (n=28) or vitamin D3 (n=24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before-versus-after comparisons were made to evaluate effects of vitamin D2 and vitamin D3 on metabolism of vitamin D. Mean post-supplementation metabolite-to-parent ratios were then compared between groups. Results: Vitamin D2 was less effective than vitamin D3 in elevating total 25(OH)D concentration. Vitamin D2 suppressed mean 4-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3 and 4β,25(OH)2D3 and mean ratios of 25(OH)D3-to-D3 and 1α,25(OH)2D3-to-25(OH)D3, while increasing the mean ratio of 24R,25(OH)2D3-to-25(OH)D3. Vitamin D3 increased mean 4-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3 and 4β,25(OH)2D3, and the mean ratio of 24R,25(OH)2D3-to-25(OH)D3. Participants receiving vitamin D2 had lower mean post-supplementation ratios of 25(OH)D3-to-vitamin D3 and 1α,25(OH)2D3-to-25(OH)D3 than those receiving vitamin D3. Mean post-supplementation ratios of 24R,25(OH)2D3-to-25(OH)D3 and 4β,25(OH)2D3-to-25(OH)D3 did not differ between groups. Conclusions: Bolus-dose vitamin D2 is less effective than bolus-dose vitamin D3 in elevating total serum 25(OH)D concentration. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-alpha hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3. PRÉCIS Data from this randomized controlled trial show that vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-alpha hydroxylation of 25(OH)D3, and increases 24R-hydroxylation of 25(OH)D3.
dc.description.sponsorshipUK Medical Research Council (MC_UP_A100_1003, MC_U106179474, MC_UU_12015/5 and MC_UU_12015/4). US National Institutes of Health (R01 GM63666).
dc.format.mediumPrinten
dc.languageengen
dc.publisherOxford University Press
dc.rightsAll rights reserved
dc.subjectHumansen
dc.subjectCholecalciferolen
dc.subjectCalcifediolen
dc.subject24,25-Dihydroxyvitamin D 3en
dc.subjectErgocalciferolsen
dc.subject25-Hydroxyvitamin D 2en
dc.subjectVitaminsen
dc.subjectDouble-Blind Methoden
dc.subjectDietary Supplementsen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.titleDifferential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.en
dc.typeArticle
prism.endingPage5839
prism.issueIdentifier12en
prism.publicationDate2019en
prism.publicationNameThe Journal of clinical endocrinology and metabolismen
prism.startingPage5831
prism.volume104en
dc.identifier.doi10.17863/CAM.40714
dcterms.dateAccepted2019-06-07en
rioxxterms.versionofrecord10.1210/jc.2019-00207en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12en
dc.contributor.orcidGriffin, Simon [0000-0002-2157-4797]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.identifier.eissn1945-7197
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/5)
pubs.funder-project-idMRC (MC_UU_12015/4)
cam.orpheus.successThu Jan 30 10:43:44 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-12-31


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