Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development
University of Cambridge
Master of Science (MSc)
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Ashcroft, A. (2019). Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development (Masters thesis). https://doi.org/10.17863/CAM.41135
DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development  but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism . Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays critical roles in a wide range of developmental processes and is implicated in several diseases, including obesity and cancer[35, 241]. Apart from a few exceptions, in the majority of processes, the precise roles and relative contributions of membrane-bound and secreted DLK1 are unknown . DLK2 is a related gene with homology to DLK1 [108, 49]; however virtually nothing is known about it. Preliminary data from the Ferguson-Smith lab suggests that it is involved in neurogenesis in the Zebrafish. This project investigates the role that DLK2 plays in wild-type mice and compares the gene to DLK1.
DLK1, DLK2, mouse model, developmental biology, zebrafish, mice, evo-devo
My work was funded by a Wellcome Trust studentship and a Lander studentship from my college.
This record's DOI: https://doi.org/10.17863/CAM.41135
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