Disease modelling in human organoids.
Huch Ortega, Meritxell
Disease models & mechanisms
Company of Biologists
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Lancaster, M. A., & Huch Ortega, M. (2019). Disease modelling in human organoids.. Disease models & mechanisms, 12 (7)https://doi.org/10.1242/dmm.039347
Abstract: The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programs, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This review and accompanying poster highlights the currently available methods, particularly those approaches modelling human biology, and provides an overview of their capabilities and limitations. We will also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.
Organoids, Animals, Humans, Models, Biological
WELLCOME TRUST (104151/Z/14/Z)
European Commission Horizon 2020 (H2020) Research Infrastructures (RI) (668350)
Embargo Lift Date
External DOI: https://doi.org/10.1242/dmm.039347
This record's URL: https://www.repository.cam.ac.uk/handle/1810/294114
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