Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk.
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McCall, S. J., Clark, A. B., Luben, R., Wareham, N., Khaw, K., & Myint, P. K. (2019). Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk.. Nutrients, 11 (7)https://doi.org/10.3390/nu11071552
Abstract Background: To investigate the demographic and lifestyles factors associated with vitamin C deficiency and to examine the association between plasma vitamin C level and self-reported physical functional health. Methods: A population-based cross-sectional study using the European Prospective Investigation into Cancer-Norfolk study. Plasma vitamin C level <11 µmol/L indicated vitamin C deficiency. Unconditional logistic regression models assessed the association between vitamin C deficiency and potential risk factors. Associations between quartiles of vitamin C and self-reported functional health measured by Short Form-36 were assessed. Results: After adjustment, vitamin C deficiency was associated with older age, being male, lower physical activity, smoking, more socially deprived area (Townsend index) and a lower educational attainment. Those in the lowest quartile of vitamin C compared to the highest were more likely to score in the lowest decile of physical function [adjusted odd ratio(aOR): 1.43 (95%CI:1.21-1.70)], bodily pain[aOR: 1.29 (95% CI: 1.07-1.56)], general health[aOR: 1.4 (95%CI:1.18-1.66)] and vitality[aOR: 1.23 (95%CI: 1.04-1.45)] SF-36 scores. Conclusions: Simple public health interventions should be aimed at populations with risk factors for vitamin C deficiency. Poor self-reported functional health was associated with lower plasma vitamin C levels, which may reflect symptoms of latent scurvy.
Humans, Neoplasms, Ascorbic Acid Deficiency, Ascorbic Acid, Risk Factors, Life Style, Socioeconomic Factors, Adult, Aged, Middle Aged, Europe, Female, Male, Self Report, United Kingdom
EPIC-Norfolk is supported by Cancer Research UK and MRC, UK. Funders had no role in design, analysis and interpretation of the study results.
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
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External DOI: https://doi.org/10.3390/nu11071552
This record's URL: https://www.repository.cam.ac.uk/handle/1810/294414
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