Mitochondrial degradation of amyloidogenic proteins - A new perspective for neurodegenerative diseases.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Lautenschäger, Janin
Kaminski Schierle, Gabriele S
Abstract
This perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (Aβ) homeostasis. Our aim is to underpin and stimulate the debate on the recent conception of mitochondria as protein degrading organelles, which suggests that mitochondria are more directly involved in neurodegenerative diseases than previously assumed.
Description
Keywords
Alpha-synuclein, Alzheimer’s disease, Amyloid beta, HtrA2, Huntingtin, Mitochondrial degradation, Neurodegeneration, Omi, Parkinson’s disease, PreP, SOD1, Amyloid beta-Peptides, Animals, Humans, Mitochondria, Neurodegenerative Diseases, alpha-Synuclein
Journal Title
Prog Neurobiol
Conference Name
Journal ISSN
0301-0082
1873-5118
1873-5118
Volume Title
181
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (089703/Z/09/Z)
Wellcome Trust (203249/Z/16/Z)
Medical Research Council (MR/K02292X/1)
Medical Research Council (G0902243)
Wellcome Trust (203249/Z/16/Z)
Medical Research Council (MR/K02292X/1)
Medical Research Council (G0902243)