Opportunities and challenges of circulating biomarkers in neuroblastoma.
The Royal Society
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Trigg, R., Shaw, J. A., & Turner, S. (2019). Opportunities and challenges of circulating biomarkers in neuroblastoma.. Open biology, 9 (5), 190056. https://doi.org/10.1098/rsob.190056
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis of tumour tissue, which is obtained through invasive surgical procedures and in some cases may not be accessible. Over the past decade, there has been growing interest in the utility of circulating biomarkers such as cell-free nucleic acids, circulating tumour cells and extracellular vesicles as a so-called liquid biopsy of cancer. Here, we review the potential of emerging circulating biomarkers in the management of neuroblastoma and highlight challenges to their implementation in the clinic.
Humans, Neuroblastoma, Neoplastic Cells, Circulating, Early Detection of Cancer, Molecular Targeted Therapy, Extracellular Vesicles, Biomarkers, Tumor, Cell-Free Nucleic Acids, Liquid Biopsy
Children with Cancer UK (16-209)
External DOI: https://doi.org/10.1098/rsob.190056
This record's URL: https://www.repository.cam.ac.uk/handle/1810/295240
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/