Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.
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Authors
Fennell, Katie A
Rambow, Florian
Lara, Luis
Yeh, Paul
Martelotto, Luciano G
Rogiers, Aljosja
Kremer, Brandon E
Barbash, Olena
Mohammad, Helai P
Johanson, Timothy M
Dhar, Arindam
Karpinich, Natalie
Tyler, Dean S
MacPherson, Laura
Pinnawala, Nathan
Yew Fong, Chun
Papenfuss, Anthony T
Kruger, Ryan G
Vakoc, Christopher R
Goode, David L
Gilan, Omer
Publication Date
2019-06-20Journal Title
Nature communications
ISSN
2041-1723
Volume
10
Issue
1
Pages
2723
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Bell, C. C., Fennell, K. A., Chan, Y., Rambow, F., Yeung, M. M., Vassiliadis, D., Lara, L., et al. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.. Nature communications, 10 (1), 2723. https://doi.org/10.1038/s41467-019-10652-9
Keywords
Cell Line, Tumor, Bone Marrow, Animals, Mice, Inbred C57BL, Humans, Mice, Trans-Activators, Antineoplastic Agents, Treatment Outcome, Xenograft Model Antitumor Assays, Sequence Analysis, RNA, Transcription, Genetic, Epigenesis, Genetic, Gene Expression Regulation, Leukemic, Drug Resistance, Neoplasm, Female, Leukemia, Myeloid, Acute, Kaplan-Meier Estimate, HEK293 Cells, Single-Cell Analysis, CRISPR-Cas Systems
Sponsorship
Cancer Research UK (20097)
Identifiers
External DOI: https://doi.org/10.1038/s41467-019-10652-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296076