Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

Bell, Charles C; Fennell, Katie A; Chan, Yih-Chih; Rambow, Florian; Yeung, Miriam M; Vassiliadis, Dane; Lara, Luis; Yeh, Paul; Martelotto, Luciano G; Rogiers, Aljosja; Kremer, Brandon E; Barbash, Olena; Mohammad, Helai P; Johanson, Timothy M; Burr, Marian; Dhar, Arindam; Karpinich, Natalie; Tian, Luyi; Tyler, Dean S; MacPherson, Laura; Shi, Junwei; Pinnawala, Nathan; Yew Fong, Chun; Papenfuss, Anthony T; Grimmond, Sean M; Dawson, Sarah-Jane; Allan, Rhys S; Kruger, Ryan G; Vakoc, Christopher R; Goode, David L; Naik, Shalin H; Gilan, Omer; Lam, Enid YN; Marine, Jean-Christophe; Prinjha, Rab K; Dawson, Mark A

View / Open Files

Published version (PDF, 5Mb)

Authors

Bell, Charles C

Fennell, Katie A

Chan, Yih-Chih

Rambow, Florian

Yeung, Miriam M

Vassiliadis, Dane

Lara, Luis

Publication Date

2019-06-20

Journal Title

Nature communications

ISSN

2041-1723

Volume

Issue

Pages

2723

Language

eng

Type

Article

This Version

VoR

Physical Medium

Electronic

Metadata

Show full item record

Citation

Bell, C. C., Fennell, K. A., Chan, Y., Rambow, F., Yeung, M. M., Vassiliadis, D., Lara, L., et al. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.. Nature communications, 10 (1), 2723. https://doi.org/10.1038/s41467-019-10652-9

Keywords

Cell Line, Tumor, Bone Marrow, Animals, Mice, Inbred C57BL, Humans, Mice, Trans-Activators, Antineoplastic Agents, Treatment Outcome, Xenograft Model Antitumor Assays, Sequence Analysis, RNA, Transcription, Genetic, Epigenesis, Genetic, Gene Expression Regulation, Leukemic, Drug Resistance, Neoplasm, Female, Leukemia, Myeloid, Acute, Kaplan-Meier Estimate, HEK293 Cells, Single-Cell Analysis, CRISPR-Cas Systems

Sponsorship

Cancer Research UK (20097)

Identifiers

External DOI: https://doi.org/10.1038/s41467-019-10652-9

This record's URL: https://www.repository.cam.ac.uk/handle/1810/296076

Rights

Attribution 4.0 International

Licence URL: https://creativecommons.org/licenses/by/4.0/

Except where otherwise noted, this item's licence is described as Attribution 4.0 International