How to test for phasic modulation of neural and behavioural responses.
Publication Date
2019-11-15Journal Title
Neuroimage
ISSN
1053-8119
Publisher
Elsevier BV
Volume
202
Pages
116175
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Zoefel, B., Davis, M., Valente, G., & Riecke, L. (2019). How to test for phasic modulation of neural and behavioural responses.. Neuroimage, 202 116175. https://doi.org/10.1016/j.neuroimage.2019.116175
Abstract
Research on whether perception or other processes depend on the phase of neural oscillations is rapidly gaining popularity. However, it is unknown which methods are optimally suited to evaluate the hypothesized phase effect. Using a simulation approach, we here test the ability of different methods to detect such an effect on dichotomous (e.g., "hit" vs "miss") and continuous (e.g., scalp potentials) response variables. We manipulated parameters that characterise the phase effect or define the experimental approach to test for this effect. For each parameter combination and response variable, we identified an optimal method. We found that methods regressing single-trial responses on circular (sine and cosine) predictors perform best for all of the simulated parameters, regardless of the nature of the response variable (dichotomous or continuous). In sum, our study lays a foundation for optimized experimental designs and analyses in future studies investigating the role of phase for neural and behavioural responses. We provide MATLAB code for the statistical methods tested.
Keywords
Brain, Neurons, Humans, Electroencephalography, Magnetoencephalography, Data Interpretation, Statistical, Perception, Models, Neurological, Computer Simulation, Transcranial Direct Current Stimulation
Sponsorship
MRC (unknown)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (743482)
Medical Research Council (MC_UU_00005/5)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1016/j.neuroimage.2019.116175
This record's URL: https://www.repository.cam.ac.uk/handle/1810/296865
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