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dc.contributor.authorRonan, Lisaen
dc.contributor.authorAlexander-Bloch, Aaronen
dc.contributor.authorFletcher, Paulen
dc.date.accessioned2019-10-01T23:30:52Z
dc.date.available2019-10-01T23:30:52Z
dc.date.issued2019-10-24en
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297347
dc.description.abstractThe development of executive function is linked to maturation of prefrontal cortex in childhood. Childhood obesity has been associated with changes in brain structure, particularly in prefrontal cortex, as well as deficits in executive functions. We aimed to determine whether differences in cortical structure mediate the relationship between executive function and childhood obesity. We analysed MR-derived measures of cortical thickness for 2,700 children between the ages of 9-11 years, recruited as part of the NIH ABCD study. We related our findings to measures of executive function and body mass index (BMI). In our analysis, increased BMI was associated with significantly reduced mean cortical thickness, as well as specific bilateral reduced cortical thickness in prefrontal cortical regions. This relationship remained after accounting for age, sex, race, parental education, household income, birth-weight and in-scanner motion. Increased BMI was also associated with lower executive function. Reduced thickness in the rostral medial and superior frontal cortex, the inferior frontal gyrus and the lateral orbitofrontal cortex partially accounted for reductions in executive function. These results suggest that childhood obesity is associated with compromised executive function. This relationship may be partly explained by BMI-associated reduced cortical thickness in the prefrontal cortex
dc.description.sponsorshipWellcome Trust Bernard Wolfe Health Neuroscience Fund
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherOxford University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleChildhood Obesity, Cortical Structure, and Executive Function in Healthy Children.en
dc.typeArticle
prism.publicationDate2019en
prism.publicationNameCerebral cortex (New York, N.Y. : 1991)en
dc.identifier.doi10.17863/CAM.44396
dcterms.dateAccepted2019-09-26en
rioxxterms.versionofrecord10.1093/cercor/bhz257en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-10-24en
dc.contributor.orcidFletcher, Paul [0000-0001-8257-1517]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095692/Z/11/Z)
pubs.funder-project-idWellcome Trust (206368/Z/17/Z)
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International