PHI-base: the pathogen-host interactions database.
Authors
Cuzick, Alayne
Seager, James
Venkatesh, Shilpa Yagwakote
Martinez, Manuel Carbajo
Publication Date
2020-01Journal Title
Nucleic acids research
ISSN
0305-1048
Publisher
Oxford University Press
Volume
48
Issue
D1
Pages
D613-D620
Language
eng
Type
Article
This Version
AM
Physical Medium
Print
Metadata
Show full item recordCitation
Urban, M., Cuzick, A., Seager, J., Wood, V., Rutherford, K., Venkatesh, S. Y., De Silva, N., et al. (2020). PHI-base: the pathogen-host interactions database.. Nucleic acids research, 48 (D1), D613-D620. https://doi.org/10.1093/nar/gkz904
Abstract
The pathogen–host interactions database (PHI-base) is available at www.phi-base.org. PHI-base contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen–host interactions reported in peer reviewed research articles. PHI-base also curates literature describing specific gene alterations that did not affect the disease interaction phenotype, in order to provide complete datasets for comparative purposes. Viruses are not included, due to their extensive coverage in other databases. In this article, we describe the increased data content of PHI-base, plus new database features and further integration with complementary databases. The release of PHI-base version 4.8 (September 2019) contains 3454 manually curated references, and provides information on 6780 genes from 268 pathogens, tested on 210 hosts in 13,801 interactions. Prokaryotic and eukaryotic pathogens are represented in almost equal numbers. Host species consist of approximately 60% plants (split 50:50 between cereal and non-cereal plants), and 40% other species of medical and/or environmental importance. The information available on pathogen effectors has risen by more than a third, and the entries for pathogens that infect crop species of global importance has dramatically increased in this release. We also briefly describe the future direction of the PHI-base project, and some existing problems with the PHI-base curation process.
Keywords
Animals, Humans, Plants, Crops, Agricultural, Communicable Diseases, Antifungal Agents, Biological Assay, Computational Biology, Phenotype, Genome, Plant, Algorithms, Internet, Databases, Factual, Host-Pathogen Interactions, Search Engine, Data Management
Sponsorship
WELLCOME TRUST (104967/Z/14/Z)
BBSRC (BB/S020098/1)
Embargo Lift Date
2022-10-11
Identifiers
External DOI: https://doi.org/10.1093/nar/gkz904
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297752
Rights
All rights reserved