Regulating heart repair with cardiac-specific T lymphocytes.
Journal of Clinical Investigation
American Society for Clinical Investigation
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Mallat, Z. (2019). Regulating heart repair with cardiac-specific T lymphocytes.. Journal of Clinical Investigation https://doi.org/10.1172/JCI132441
Cardiac tissue necrosis secondary to coronary artery occlusion is one of the most common and deadly sterile injuries in developed countries. In this issue of the JCI, Rieckmann et al. identified and characterized antigen-specific CD4+ T helper (Th) cells that developed in the context of myocardial infarction (MI) in mice. They showed that myosin heavy chain α (MYHCA) is a dominant cardiac autoantigen and that T cells with T cell receptor (TCR) specificity to MYHCA acquired a Treg phenotype when adoptively transferred into infarcted mice, which mediated a cardioprotective healing response. Thus, Rieckmann et al. showed that an acute ischemic insult to the heart, which induces sterile inflammation, promoted, rather than limited, protective T cell autoimmunity. Notably, strategies that support an antigen-specific Treg response may limit the immune-inflammatory response and promote cardiac repair after acute MI.
This work is supported by the British Heart Foundation (United Kingdom), INSERM (France), and the European Research Council.
British Heart Foundation (RG/15/11/31593)
External DOI: https://doi.org/10.1172/JCI132441
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297918
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