A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.
Chemistry (Weinheim an der Bergstrasse, Germany)
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Watanabe, E., Chen, Y., May, O., & Ley, S. (2020). A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.. Chemistry (Weinheim an der Bergstrasse, Germany), 26 (1), 186-191. https://doi.org/10.1002/chem.201905048
A practically useful coupling reaction between aromatic halides and redox-active esters was realized via nickel catalysis through the use of packed zinc bed column in continuous flow. Multiple reuse of the column showed a negligible decrease in efficiency, affording high space/time yields. A wide range of substrates, including a number of heteroaryl halides and polyfunctional materials were coupled in generally good yields. Longer-time and larger-scale experiments further demonstrates the robustness of the system.
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
External DOI: https://doi.org/10.1002/chem.201905048
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298746
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