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dc.contributor.authorBergstralh, Danielen
dc.contributor.authorDawney, Nicole Sen
dc.contributor.authorSt Johnston, Danielen
dc.date.accessioned2019-11-29T00:30:39Z
dc.date.available2019-11-29T00:30:39Z
dc.date.issued2017-04en
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299430
dc.description.abstractThe direction in which a cell divides is determined by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. In multiple cell types in multiple animals, spindle orientation is controlled by a conserved biological machine that mediates a pulling force on astral microtubules. Restricting the localization of this machine to only specific regions of the cortex can thus determine how the mitotic spindle is oriented. As we review here, recent findings based on studies in tunicate, worm, fly and vertebrate cells have revealed that the mechanisms for mediating this restriction are surprisingly diverse.
dc.description.sponsorshipThe Wellcome Trust
dc.format.mediumPrinten
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectMicrotubulesen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectGTP-Binding Protein alpha Subunits, Gi-Goen
dc.subjectCell Divisionen
dc.subjectCell Shapeen
dc.subjectModels, Biologicalen
dc.subjectSpindle Apparatusen
dc.titleSpindle orientation: a question of complex positioning.en
dc.typeArticle
prism.endingPage1145
prism.issueIdentifier7en
prism.publicationDate2017en
prism.publicationNameDevelopment (Cambridge, England)en
prism.startingPage1137
prism.volume144en
dc.identifier.doi10.17863/CAM.46499
dcterms.dateAccepted2017-01-10en
rioxxterms.versionofrecord10.1242/dev.140764en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-04en
dc.contributor.orcidBergstralh, Daniel [0000-0003-1689-3715]
dc.contributor.orcidSt Johnston, Daniel [0000-0001-5582-3301]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Reviewen


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