The mechanism of balloon Eustachian tuboplasty: a biomechanical study.
Medical & biological engineering & computing
MetadataShow full item record
Smith, M. E., Weir, A. E., Prior, D. C., Cope, W., Tysome, J. R., & Sutcliffe, M. (2020). The mechanism of balloon Eustachian tuboplasty: a biomechanical study.. Medical & biological engineering & computing, 58 (4), 689-699. https://doi.org/10.1007/s11517-020-02121-z
Obstructive Eustachian tube dysfunction (OETD) is a common condition resulting from inadequate opening of the Eustachian tube (ET). A new surgical treatment involves high pressure inflation of a balloon within the ET, with the aim of dilating the soft tissue structure. However, the mechanical effects of this intervention have not been established, nor the impact of changing device size or other technical parameters. A novel experimental technique allowed quantification of plastic and elastic tissue deformation in model materials and then human cadaver ETs during balloon dilation, based on the measured balloon inflation pressure-volume relationship. Plastic tissue deformation was found to be greater using larger balloons and deeper device insertion, but increasing the inflation pressure had a more limited effect, with most deformation occurring well below the clinically used pressures. Histological assessment of ET tissue suggested that mucosal tearing and cartilage cracking were in part responsible for the mechanical changes. Balloon dilation of the ET has huge potential if found to be clinically effective, but currently there is a need to understand and develop the technique further. The novel methods employed in this study will be valuable in future laboratory and in vivo studies of ET balloon dilation.
Cambridge Hearing Trust, Cambridge University Engineering Department
Embargo Lift Date
External DOI: https://doi.org/10.1007/s11517-020-02121-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300500