Macroautophagy without LC3 conjugation?
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Publication Date
2017-01Journal Title
Cell research
ISSN
1001-0602
Volume
27
Issue
1
Pages
5-6
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
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Renna, M., & Rubinsztein, D. (2017). Macroautophagy without LC3 conjugation?. Cell research, 27 (1), 5-6. https://doi.org/10.1038/cr.2016.143
Abstract
A recent study makes the surprising observation that autophagosomes can still form in the absence of the core conjugation machinery. Furthermore, while such autophagosomes can fuse with lysosomes, their degradation is delayed, and this is associated with delayed destruction of the inner autophagosomal double membrane, highlighting a new role for proteins thought to act exclusively in the formation of autophagosomes in late stages of the autophagic itinerary within autolysosomes.
Keywords
Hela Cells, Lysosomes, Phagosomes, Humans, Autophagy
Identifiers
External DOI: https://doi.org/10.1038/cr.2016.143
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300647
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