Macroautophagy without LC3 conjugation?
Authors
Renna, Maurizio
Rubinsztein, David C
Change log
Abstract
A recent study makes the surprising observation that autophagosomes can still form in the absence of the core conjugation machinery. Furthermore, while such autophagosomes can fuse with lysosomes, their degradation is delayed, and this is associated with delayed destruction of the inner autophagosomal double membrane, highlighting a new role for proteins thought to act exclusively in the formation of autophagosomes in late stages of the autophagic itinerary within autolysosomes.
Publication Date
2017-01
Online Publication Date
2016-12-06
Acceptance Date
2016-11-20
Keywords
Autophagy, HeLa Cells, Humans, Lysosomes, Phagosomes
Journal Title
Cell Res
Journal ISSN
1001-0602
1748-7838
1748-7838
Volume Title
27
Publisher
Springer Science and Business Media LLC