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dc.contributor.authorde Groot, Marius
dc.contributor.authorPatel, Neel
dc.contributor.authorManavaki, Roido
dc.contributor.authorJaniczek, Robert L
dc.contributor.authorBergstrom, Mats
dc.contributor.authorÖstör, Andrew
dc.contributor.authorGerlag, Danielle
dc.contributor.authorRoberts, Alexandra
dc.contributor.authorGraves, Martin J
dc.contributor.authorKarkera, Yakshitha
dc.contributor.authorFernando, Disala
dc.contributor.authorMistry, Prafull
dc.contributor.authorWalker, Adam
dc.contributor.authorWisniacki, Nicolas
dc.contributor.authorFryer, Tim D
dc.contributor.authorJimenez-Royo, Pilar
dc.date.accessioned2020-01-28T01:35:33Z
dc.date.available2020-01-28T01:35:33Z
dc.date.issued2019-12-19
dc.identifier.issn2191-219X
dc.identifier.other31858293
dc.identifier.otherPMC6923307
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301363
dc.description.abstractPURPOSE:While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable. Various imaging probes have shown value including dynamic contrast-enhanced (DCE) MRI and PET/CT using 18F-fluorodeoxyglucose (18F-FDG) or tracers targeting the translocator protein (TSPO). To evaluate 18F-GE-180, a novel TSPO PET tracer, for detecting and quantifying disease activity in RA, we compared 18F-GE-180 uptake with that of 18F-FDG and DCE-MRI measures of inflammation. METHODS:Eight RA patients with moderate-to-high, stable disease activity and active disease in at least one wrist were included in this study (NCT02350426). Participants underwent PET/CT examinations with 18F-GE-180 and 18F-FDG on separate visits, covering the shoulders and from the pelvis to the feet, including hands and wrists. DCE-MRI was performed on one affected hand. Uptake was compared visually between tracers as judged by an experienced radiologist and quantitatively using the maximum standardised uptake value (SUVmax). Uptake for both tracers was correlated with DCE-MRI parameters of inflammation, including the volume transfer coefficient Ktrans using Pearson correlation (r). RESULTS:PET/CT imaging with 18F-GE-180 in RA patients showed marked extra-synovial uptake around the affected joints. Overall sensitivity for detecting clinically affected joints was low (14%). 18F-GE-180 uptake did not or only weakly correlate with DCE-MRI parameters in the wrist (r = 0.09-0.31). 18F-FDG showed higher sensitivity for detecting symptomatic joints (34%), as well as strong positive correlation with DCE-MRI parameters (SUVmax vs. Ktrans: r = 0.92 for wrist; r = 0.68 for metacarpophalangeal joints). CONCLUSIONS:The correlations between DCE-MRI parameters and 18F-FDG uptake support use of this PET tracer for quantification of inflammatory burden in RA. The TSPO tracer 18F-GE-180, however, has shown limited use for the investigation of RA due to its poor sensitivity and ability to quantify disease activity in RA.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2191-219X
dc.sourcenlmid: 101560946
dc.subjectRheumatoid arthritis
dc.subjectMRI
dc.subjectPET
dc.subjectFdg
dc.subjectTspo
dc.titleQuantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
dc.typeArticle
dc.date.updated2020-01-28T01:35:32Z
dc.identifier.doi10.17863/CAM.48444
rioxxterms.versionofrecord10.1186/s13550-019-0576-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJimenez-Royo, Pilar [0000-0003-1959-6791]
pubs.funder-project-idGlaxoSmithKline (NA)
pubs.funder-project-idNational Institute for Health Research, Cambridge Biomedical Research Centre (N/A)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International