Endoplasmic reticulum stress in malignancy.

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Authors
Clarke, Hanna J
  Chambers, Joseph
Liniker, Elizabeth
  Marciniak, Stefan
Publication Date
2014-05-12
Journal Title
Cancer Cell
ISSN
1535-6108
Publisher
Elsevier BV
Volume
25
Issue
5
Pages
563-573
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print
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Citation
Clarke, H. J., Chambers, J., Liniker, E., & Marciniak, S. (2014). Endoplasmic reticulum stress in malignancy.. Cancer Cell, 25 (5), 563-573. https://doi.org/10.1016/j.ccr.2014.03.015
Abstract
The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
Keywords
Endoplasmic Reticulum, Humans, Neoplasms, Neovascularization, Pathologic, Boronic Acids, Pyrazines, Endoribonucleases, Protein-Serine-Threonine Kinases, eIF-2 Kinase, Antineoplastic Agents, Cell Proliferation, Cell Survival, Protein Folding, Activating Transcription Factor 6, Unfolded Protein Response, Endoplasmic Reticulum Stress, Bortezomib
Sponsorship
Medical Research Council (G1002610)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)
Identifiers
External DOI: https://doi.org/10.1016/j.ccr.2014.03.015
This record's URL: https://www.repository.cam.ac.uk/handle/1810/301417
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International