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dc.contributor.authorVatansever, Den
dc.contributor.authorSchröter, Men
dc.contributor.authorAdapa, RMen
dc.contributor.authorBullmore, Edwarden
dc.contributor.authorMenon, Daviden
dc.contributor.authorStamatakis, Emmanuelen
dc.date.accessioned2020-02-05T00:30:22Z
dc.date.available2020-02-05T00:30:22Z
dc.date.issued2020-02-25en
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301728
dc.description.abstractPatterns of functional interactions across distributed brain regions are suggested to provide a scaffold for the conscious processing of information, with marked topological alterations observed in loss of consciousness. However, establishing a firm link between macro-scale brain network organisation and conscious cognition requires direct investigations into neuropsychologically-relevant architectural modifications across systematic reductions in consciousness. Here we assessed both global and regional disturbances to brain graphs in a group of healthy participants across baseline resting state fMRI as well as two distinct levels of propofol-induced sedation. We found a persistent modular architecture, yet significant reorganisation of brain hubs that formed parts of a wider rich-club collective. Furthermore, the reduction in the strength of rich-club connectivity was significantly associated with the participants’ performance in a semantic judgment task, indicating the importance of this higher-order topological feature for conscious cognition. These results highlight a remarkable interplay between global and regional properties of brain functional interactions in supporting conscious cognition that is relevant to our understanding of clinical disorders of consciousness.
dc.description.sponsorshiphis research study was funded by a Wellcome Trust Clinical Research Training Fellowship awarded to R.M.A. (Contract grant number: 083660/Z/07/Z). Additionally, this work was supported by grants from the Yousef Jameel Academic Program administered via the Cambridge Trust, the Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01) and ZJLab awarded to D.V.; the National Institute for Health Research (NIHR, UK), Cambridge Biomedical Research Centre and NIHR Senior Investigator Awards to D.K.M.; The Canadian Institute for Advanced Research (CIFAR) to D.K.M. and E.A.S.; the Stephen Erskine Fellowship (Queens’ College, Cambridge) to E.A.S.; the British Oxygen Professorship of the Royal College of Anaesthetists to D.K.M. This research was also supported by the NIHR Brain Injury Healthcare Technology Co-operative based at Cambridge University Hospitals NHS Foundation Trust and University of Cambridge.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherNature Publishing Group
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectBrainen
dc.subjectNerve Neten
dc.subjectNeural Pathwaysen
dc.subjectHumansen
dc.subjectUnconsciousnessen
dc.subjectPropofolen
dc.subjectMagnetic Resonance Imagingen
dc.subjectConscious Sedationen
dc.subjectConsciousnessen
dc.subjectAdulten
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.titleReorganisation of Brain Hubs across Altered States of Consciousness.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameScientific reportsen
prism.startingPage3402
prism.volume10en
dc.identifier.doi10.17863/CAM.48800
dcterms.dateAccepted2020-01-31en
rioxxterms.versionofrecord10.1038/s41598-020-60258-1en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-02-25en
dc.contributor.orcidVatansever, D [0000-0002-2494-9945]
dc.contributor.orcidAdapa, RM [0000-0002-9845-8532]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidStamatakis, Emmanuel Andreas [0000-0001-6955-9601]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (083660/Z/07/Z)
pubs.funder-project-idMRC (MC_G0802534)
cam.orpheus.successMon Jun 08 08:20:13 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2023-02-04


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