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dc.contributor.authorWang, Zhengmingen
dc.contributor.authorBaulcombe, Daviden
dc.date.accessioned2020-02-14T00:32:00Z
dc.date.available2020-02-14T00:32:00Z
dc.date.issued2020-03-06en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302171
dc.description.abstractSilencing of transposable elements (TEs) is established by small RNA-directed DNA methylation (RdDM). Maintenance of silencing is then based on a combination of RdDM and RNA-independent mechanisms involving DNA methyltransferase MET1 and chromodomain DNA methyltransferases (CMTs). Involvement of RdDM, according to this model should decrease with TE age but here we show a different pattern in tomato and Arabidopsis. In these species the CMTs silence long terminal repeat (LTR) transposons in the distal chromatin that are younger than those affected by RdDM. To account for these findings we propose that, after establishment of primary RdDM as in the original model, there is an RNA-independent maintenance phase involving CMTs followed by secondary RdDM. This progression of epigenetic silencing in the gene-rich distal chromatin is likely to influence the transcriptome either in cis or in trans depending on whether the mechanisms are RNA-dependent or -independent.
dc.description.sponsorshipThis work was supported by European Research Council Advanced Investigator grant ERC-2013-AdG 340642 (Transgressive Inheritance in plant Breeding and Evolution [TRIBE]), the Royal Society (RP170001), the Balzan Foundation and BBSRC grant BB/R018529/1. D.C.B. is the Royal Society Edward Penley Abraham Research Professor.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectChromatinen
dc.subjectLycopersicon esculentumen
dc.subjectRNA Polymerase IIen
dc.subjectNucleotidesen
dc.subjectPlant Proteinsen
dc.subjectDNA Transposable Elementsen
dc.subjectEvolution, Molecularen
dc.subjectDNA Methylationen
dc.subjectGene Silencingen
dc.subjectTerminal Repeat Sequencesen
dc.subjectPhenotypeen
dc.subjectMutationen
dc.subjectCRISPR-Cas Systemsen
dc.titleTransposon age and non-CG methylation.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameNature communicationsen
prism.startingPage1221
prism.volume11en
dc.identifier.doi10.17863/CAM.49247
dcterms.dateAccepted2020-02-11en
rioxxterms.versionofrecord10.1038/s41467-020-14995-6en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-03-06en
dc.contributor.orcidWang, Zhengming [0000-0003-0384-5714]
dc.contributor.orcidBaulcombe, David [0000-0003-0780-6878]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idInternational Balzan Prize Foundation (10957)
pubs.funder-project-idRoyal Society (RP170001)
pubs.funder-project-idRoyal Society (RP/EA/180018)
pubs.funder-project-idBBSRC (BB/R018529/1)
pubs.funder-project-idEuropean Research Council (340642)
cam.orpheus.successMon Jun 08 08:21:04 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2023-02-13


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