Show simple item record

dc.contributor.authorLodge
dc.contributor.authorCowburn
dc.contributor.authorLi
dc.contributor.authorCondliffe
dc.date.accessioned2020-02-14T01:11:17Z
dc.date.available2020-02-14T01:11:17Z
dc.date.issued2020-02-11
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302178
dc.description.abstractNeutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of neutrophil extracellular traps; all of these microbicidal strategies require the deployment of cytotoxic proteins and proteases, packaged during neutrophil development within cytoplasmic granules. Neutrophils operate in infected and inflamed tissues, which can be profoundly hypoxic. Neutrophilic infiltration of hypoxic tissues characterises a myriad of acute and chronic infectious and inflammatory diseases, and as well as potentially protecting the host from pathogens, neutrophil granule products have been implicated in causing collateral tissue damage in these scenarios. This review discusses the evidence for the enhanced secretion of destructive neutrophil granule contents observed in hypoxic environments and the potential mechanisms for this heightened granule exocytosis, highlighting implications for the host. Understanding the dichotomy of the beneficial and detrimental consequences of neutrophil degranulation in hypoxic environments is crucial to inform potential neutrophil-directed therapeutics in order to limit persistent, excessive, or inappropriate inflammation.
dc.languageen
dc.publisherMDPI
dc.subjectneutrophils
dc.subjecthypoxia
dc.subjectdegranulation
dc.titleThe Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
dc.typeArticle
dc.date.updated2020-02-14T01:11:17Z
prism.issueIdentifier4
prism.publicationNameInternational Journal of Molecular Sciences
prism.volume21
dc.identifier.doi10.17863/CAM.49254
dcterms.dateAccepted2020-02-08
rioxxterms.versionofrecord10.3390/ijms21041183
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1422-0067
pubs.funder-project-idMedical Research Council (MR/No2995X/1)
pubs.funder-project-idBMA Foundation for Medical Research (Josephine Lansdell 2017)


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record