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dc.contributor.authorEscala-Garcia, Maria
dc.contributor.authorAbraham, Jean
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorArndt, Volker
dc.contributor.authorAshworth, Alan
dc.contributor.authorAuer, Paul L
dc.contributor.authorAuvinen, Päivi
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorBehrens, Sabine
dc.contributor.authorBenitez, Javier
dc.contributor.authorBermisheva, Marina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorBlot, William
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorBojesen, Stig E
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBrucker, Sara Y
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorCaldas, Carlos
dc.contributor.authorCanzian, Federico
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorChanock, Stephen J
dc.contributor.authorChin, Suet-Feung
dc.contributor.authorClarke, Christine L
dc.contributor.authorCouch, Fergus J
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S
dc.contributor.authorCzene, Kamila
dc.contributor.authorDaly, Mary B
dc.contributor.authorDennis, Joe
dc.contributor.authorDevilee, Peter
dc.contributor.authorDunn, Janet A
dc.contributor.authorDunning, Alison M
dc.contributor.authorDwek, Miriam
dc.contributor.authorEarl, Helena M
dc.contributor.authorEccles, Diana M
dc.contributor.authorEliassen, A Heather
dc.contributor.authorEllberg, Carolina
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFasching, Peter A
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorFlyger, Henrik
dc.contributor.authorGago-Dominguez, Manuela
dc.contributor.authorGapstur, Susan M
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorGarcía-Sáenz, José A
dc.contributor.authorGaudet, Mia M
dc.contributor.authorGeorge, Angela
dc.contributor.authorGiles, Graham G
dc.contributor.authorGoldgar, David E
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorGrip, Mervi
dc.contributor.authorGuénel, Pascal
dc.contributor.authorGuo, Qi
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHåkansson, Niclas
dc.contributor.authorHamann, Ute
dc.contributor.authorHarrington, Patricia A
dc.contributor.authorHiller, Louise
dc.contributor.authorHooning, Maartje J
dc.contributor.authorHopper, John L
dc.contributor.authorHowell, Anthony
dc.contributor.authorHuang, Chiun-Sheng
dc.contributor.authorHuang, Guanmengqian
dc.contributor.authorHunter, David J
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJohn, Esther M
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKapoor, Pooja Middha
dc.contributor.authorKeeman, Renske
dc.contributor.authorKitahara, Cari M
dc.contributor.authorKoppert, Linetta B
dc.contributor.authorKraft, Peter
dc.contributor.authorKristensen, Vessela N
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorLindblom, Annika
dc.contributor.authorLubiński, Jan
dc.contributor.authorMannermaa, Arto
dc.contributor.authorManoochehri, Mehdi
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorMargolin, Sara
dc.contributor.authorMartinez, Maria Elena
dc.contributor.authorMaurer, Tabea
dc.contributor.authorMavroudis, Dimitrios
dc.contributor.authorMeindl, Alfons
dc.contributor.authorMilne, Roger L
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNewman, William G
dc.contributor.authorOlshan, Andrew F
dc.contributor.authorOlson, Janet E
dc.contributor.authorOlsson, Håkan
dc.contributor.authorOrr, Nick
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPetridis, Christos
dc.contributor.authorPrentice, Ross L
dc.contributor.authorPresneau, Nadege
dc.contributor.authorPunie, Kevin
dc.contributor.authorRamachandran, Dhanya
dc.contributor.authorRennert, Gad
dc.contributor.authorRomero, Atocha
dc.contributor.authorSachchithananthan, Mythily
dc.contributor.authorSaloustros, Emmanouil
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorSchwentner, Lukas
dc.contributor.authorScott, Christopher
dc.contributor.authorSimard, Jacques
dc.contributor.authorSohn, Christof
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorTamimi, Rulla M
dc.contributor.authorTapper, William J
dc.contributor.authorTeixeira, Manuel R
dc.contributor.authorTerry, Mary Beth
dc.contributor.authorThorne, Heather
dc.contributor.authorTollenaar, Rob A E M
dc.contributor.authorTomlinson, Ian
dc.contributor.authorTroester, Melissa A
dc.contributor.authorTruong, Thérèse
dc.contributor.authorTurnbull, Clare
dc.contributor.authorVachon, Celine M
dc.contributor.authorvan der Kolk, Lizet E
dc.contributor.authorWang, Qin
dc.contributor.authorWinqvist, Robert
dc.contributor.authorWolk, Alicja
dc.contributor.authorYang, Xiaohong R
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorHall, Per
dc.contributor.authorWessels, Lodewyk F A
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBader, Gary D
dc.contributor.authorDörk, Thilo
dc.contributor.authorEaston, Douglas F
dc.contributor.authorCanisius, Sander
dc.contributor.authorSchmidt, Marjanka K
dc.date.accessioned2020-02-19T11:33:19Z
dc.date.available2020-02-19T11:33:19Z
dc.date.issued2020-01-16
dc.identifier.issn2041-1723
dc.identifier.otherPMC6965101
dc.identifier.other31949161
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302377
dc.description.abstractIdentifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleA network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
dc.typeArticle
dc.date.updated2020-02-19T11:33:18Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume11
dc.identifier.doi10.17863/CAM.49449
rioxxterms.versionofrecord10.1038/s41467-019-14100-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAndrulis, Irene L [0000-0002-4226-6435]
dc.contributor.orcidArndt, Volker [0000-0001-9320-8684]
dc.contributor.orcidBlomqvist, Carl [0000-0003-3041-1938]
dc.contributor.orcidBojesen, Stig E [0000-0002-4061-4133]
dc.contributor.orcidBrauch, Hiltrud [0000-0001-7531-2736]
dc.contributor.orcidCaldas, Carlos [0000-0003-3547-1489]
dc.contributor.orcidCanzian, Federico [0000-0002-4261-4583]
dc.contributor.orcidChanock, Stephen J [0000-0002-2324-3393]
dc.contributor.orcidChin, Suet-Feung [0000-0001-5697-1082]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidDevilee, Peter [0000-0002-8023-2009]
dc.contributor.orcidDunning, Alison M [0000-0001-6651-7166]
dc.contributor.orcidDwek, Miriam [0000-0001-7184-2932]
dc.contributor.orcidEarl, Helena M [0000-0003-1549-8094]
dc.contributor.orcidEllberg, Carolina [0000-0001-7297-0645]
dc.contributor.orcidFasching, Peter A [0000-0003-4885-8471]
dc.contributor.orcidGarcía-Closas, Montserrat [0000-0003-1033-2650]
dc.contributor.orcidGarcía-Sáenz, José A [0000-0001-6880-0301]
dc.contributor.orcidGiles, Graham G [0000-0003-4946-9099]
dc.contributor.orcidGuénel, Pascal [0000-0002-8359-518X]
dc.contributor.orcidHåkansson, Niclas [0000-0001-7673-5554]
dc.contributor.orcidHowell, Anthony [0000-0002-6233-719X]
dc.contributor.orcidKapoor, Pooja Middha [0000-0001-5503-8215]
dc.contributor.orcidKeeman, Renske [0000-0002-5452-9933]
dc.contributor.orcidKraft, Peter [0000-0002-4472-8103]
dc.contributor.orcidLambrechts, Diether [0000-0002-3429-302X]
dc.contributor.orcidMilne, Roger L [0000-0001-5764-7268]
dc.contributor.orcidNevanlinna, Heli [0000-0002-0916-2976]
dc.contributor.orcidNewman, William G [0000-0002-6382-4678]
dc.contributor.orcidOlson, Janet E [0000-0003-4944-7789]
dc.contributor.orcidOlsson, Håkan [0000-0002-8794-9635]
dc.contributor.orcidOrr, Nick [0000-0003-2866-942X]
dc.contributor.orcidPeterlongo, Paolo [0000-0001-6951-6855]
dc.contributor.orcidPunie, Kevin [0000-0002-1162-7963]
dc.contributor.orcidRamachandran, Dhanya [0000-0001-8139-7799]
dc.contributor.orcidRennert, Gad [0000-0002-8512-068X]
dc.contributor.orcidRomero, Atocha [0000-0002-1634-7397]
dc.contributor.orcidSaloustros, Emmanouil [0000-0002-0485-0120]
dc.contributor.orcidScott, Christopher [0000-0003-1340-0647]
dc.contributor.orcidSimard, Jacques [0000-0001-6906-3390]
dc.contributor.orcidTeixeira, Manuel R [0000-0002-4896-5982]
dc.contributor.orcidTomlinson, Ian [0000-0003-3037-1470]
dc.contributor.orcidTruong, Thérèse [0000-0002-2943-6786]
dc.contributor.orcidWinqvist, Robert [0000-0003-0932-9104]
dc.contributor.orcidWolk, Alicja [0000-0001-7387-6845]
dc.contributor.orcidZiogas, Argyrios [0000-0003-4529-3727]
dc.contributor.orcidPharoah, Paul D P [0000-0001-8494-732X]
dc.contributor.orcidBader, Gary D [0000-0003-0185-8861]
dc.contributor.orcidDörk, Thilo [0000-0002-9458-0282]
dc.contributor.orcidEaston, Douglas F [0000-0003-2444-3247]
dc.contributor.orcidCanisius, Sander [0000-0003-3888-8829]
dc.contributor.orcidSchmidt, Marjanka K [0000-0002-2228-429X]
pubs.funder-project-idNHLBI NIH HHS (HHSN268201100046C, HHSN268201100001I, HHSN268201100002I, HHSN268201100004I)
pubs.funder-project-idNIA NIH HHS (HHSN271201100004C)
pubs.funder-project-idNCI NIH HHS (P50 CA116201, R01 CA128931, U01 CA098758, U01 CA179715, U19 CA148065, R01 CA097396, R01 CA177150, R01 CA192393, UM1 CA164917, UM1 CA164920, UM1 CA164973, UM1 CA176726, P50 CA058223, R01 CA063464, R01 CA132839, U01 CA063464, U01 CA164973, U19 CA148112, K07 CA092044, P01 CA087969, R01 CA140286, R01 CA176785, R37 CA054281, U01 CA058860, U01 CA116167, UM1 CA186107, R01 CA054281, U19 CA148537, R01 CA058860, R01 CA077398, R01 CA116167, R01 CA128978, U01 CA199277, U54 CA156733)
pubs.funder-project-idWHI NIH HHS (HHSN268201100003C, HHSN268201100001C, HHSN268201100002C, HHSN268201100004C)
pubs.funder-project-idCancer Foundation Finland sr (160104)
pubs.funder-project-idEuropean Research Council (294576)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International