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dc.contributor.authorLin, Rong
dc.contributor.authorYuan, Ziyu
dc.contributor.authorZhang, Caicai
dc.contributor.authorJu, Hongfang
dc.contributor.authorSun, Yuantian
dc.contributor.authorHuang, Na
dc.contributor.authorChen, Langxin
dc.contributor.authorJin, Li
dc.date.accessioned2020-03-12T21:09:39Z
dc.date.available2020-03-12T21:09:39Z
dc.date.issued2020-03-12
dc.date.submitted2019-10-26
dc.identifier.otherpone-d-19-29925
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303343
dc.description.abstractTwo meta-analysis of genome wide association studies identified two variants at adenylate cyclase 5 (ADCY5) associated with type 2 diabetes mellitus, fasting and 2-hour glucose in non-pregnant individuals of European descent. The objective of our study was to explore the role of common variants in ADCY5 on gestational glycemic traits, including plasma glucose, insulin values, β cell function and insulin resistance in the fasted state as well as plasma glucose 1 hour after a 50-gram glucose challenge test among Chinese Han women. Homoeostasis model assessment (HOMA) was used to quantify β cell function (HOMA1-β and HOMA2-β) and insulin resistance (HOMA1-IR and HOMA2-IR). Thirty-five single nucleotide polymorphisms (SNPs) in ADCY5 were genotyped in 929 unrelated Chinese Han women with singleton pregnancies. Three SNPs (rs6797915, rs9856662 and rs9875803) displayed evidence for association with plasma glucose 1 hour after a 50-gram glucose challenge test (P = 0.042, 0.018 and 0.018, respectively), one (rs6777397) displayed evidence for association with HOMA1-β (P = 0.014), and one (rs6762009) displayed evidence for association with HOMA1-IR (P = 0.033). These results provide additional insight into the effects of genetic variation within ADCY5 in glucose metabolism, especially during pregnancy and in non-European descent populations.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectPeople and places
dc.titleCommon genetic variants in ADCY5 and gestational glycemic traits
dc.typeArticle
dc.date.updated2020-03-12T21:09:39Z
prism.issueIdentifier3
prism.publicationNamePLOS ONE
prism.volume15
dc.identifier.doi10.17863/CAM.50431
dcterms.dateAccepted2020-02-19
rioxxterms.versionofrecord10.1371/journal.pone.0230032
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Petry, Clive J.
dc.contributor.orcidLin, Rong [0000-0001-9161-6844]
dc.identifier.eissn1932-6203


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)