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dc.contributor.authorDiaz-Guevara, Paula
dc.contributor.authorMontaño, Lucy Angeline
dc.contributor.authorDuarte, Carolina
dc.contributor.authorZabaleta, Gabriela
dc.contributor.authorMaes, Mailis
dc.contributor.authorMartinez Angarita, Julio Cesar
dc.contributor.authorThanh, Duy Pham
dc.contributor.authorLeón-Quevedo, William
dc.contributor.authorCastañeda-Orjuela, Carlos
dc.contributor.authorAlvarez Alvarez, Claudia Jimena
dc.contributor.authorGuerrero, Jaime
dc.contributor.authorMoroni, Miriam
dc.contributor.authorCampos, Josefina
dc.contributor.authorPérez, Enrique
dc.contributor.authorBaker, Stephen
dc.date.accessioned2020-03-25T11:23:14Z
dc.date.available2020-03-25T11:23:14Z
dc.date.issued2020-03-10
dc.date.submitted2019-07-26
dc.identifier.otherpntd-d-19-01222
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303726
dc.descriptionFunder: Instituto Nacional de Salud, Bogotá, Colombia
dc.description.abstractSalmonella Typhi (S. Typhi) is the causative agent of typhoid fever; a systemic disease affecting ~20 million people per year globally. There are little data regarding the contemporary epidemiology of typhoid in Latin America. Consequently, we aimed to describe some recent epidemiological aspects of typhoid in Colombia using cases reported to the National Public Health Surveillance System (Sivigila) between 2012 and 2015. Over the four-year reporting period there were 836 culture confirmed cases of typhoid in Colombia, with the majority (676/836; 80.1%) of reported cases originated from only seven departments. We further characterized 402 S. Typhi isolates with available corresponding data recovered from various departments of Colombia through antimicrobial susceptibility testing and molecular subtyping. The majority (235/402; 58.5%) of these typhoid cases occurred in males and were most commonly reported in those aged between 10 and 29 years (218/402; 54.2%); there were three (0.74%) reported fatalities. The overwhelming preponderance (339/402; 84.3%) of S. Typhi were susceptible to all tested antimicrobials. The most common antimicrobial to which the organisms exhibited non-susceptibility was ampicillin (30/402;7.5%), followed by nalidixic acid (23/402, 5.7%). Molecular subtyping identified substantial genetic diversity, which was well distributed across the country. Despite the diffuse pattern of S. Typhi genotypes, we identified various geographical hotspots of disease associated with local dominant genotypes. Notably, we found limited overlap of Colombian genotypes with organisms reported in other Latin American countries. Our work highlights a substantial burden of typhoid in Colombia, characterized by sustained transmission in some regions and limited epidemics in other departments. The disease is widely distributed across the country and associated with multiple antimicrobial susceptible genotypes that appear to be restricted to Colombia. This study provides a current perspective for typhoid in Latin America and highlights the importance of pathogen-specific surveillance to add insight into the limited epidemiology of typhoid in this region.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectMedicine and health sciences
dc.subjectBiology and life sciences
dc.subjectPeople and places
dc.subjectEcology and environmental sciences
dc.subjectEarth sciences
dc.titleSurveillance of Salmonella enterica serovar Typhi in Colombia, 2012–2015
dc.typeArticle
dc.date.updated2020-03-25T11:23:13Z
prism.issueIdentifier3
prism.publicationNamePLOS Neglected Tropical Diseases
prism.volume14
dc.identifier.doi10.17863/CAM.50805
dcterms.dateAccepted2020-01-09
rioxxterms.versionofrecord10.1371/journal.pntd.0008040
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Azman, Andrew S.
dc.contributor.orcidDiaz-Guevara, Paula [0000-0002-8252-5622]
dc.contributor.orcidBaker, Stephen [0000-0003-1308-5755]
dc.identifier.eissn1935-2735


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)