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dc.contributor.authorVatansever, D
dc.contributor.authorSchröter, M
dc.contributor.authorAdapa, R M
dc.contributor.authorBullmore, E T
dc.contributor.authorMenon, D K
dc.contributor.authorStamatakis, E A
dc.date.accessioned2020-03-29T01:24:21Z
dc.date.available2020-03-29T01:24:21Z
dc.date.issued2020-02-25
dc.identifier.issn2045-2322
dc.identifier.otherPMC7042369
dc.identifier.other32099008
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303874
dc.descriptionFunder: Wellcome Trust
dc.description.abstractPatterns of functional interactions across distributed brain regions are suggested to provide a scaffold for the conscious processing of information, with marked topological alterations observed in loss of consciousness. However, establishing a firm link between macro-scale brain network organisation and conscious cognition requires direct investigations into neuropsychologically-relevant architectural modifications across systematic reductions in consciousness. Here we assessed both global and regional disturbances to brain graphs in a group of healthy participants across baseline resting state fMRI as well as two distinct levels of propofol-induced sedation. We found a persistent modular architecture, yet significant reorganisation of brain hubs that formed parts of a wider rich-club collective. Furthermore, the reduction in the strength of rich-club connectivity was significantly associated with the participants' performance in a semantic judgment task, indicating the importance of this higher-order topological feature for conscious cognition. These results highlight a remarkable interplay between global and regional properties of brain functional interactions in supporting conscious cognition that is relevant to our understanding of clinical disorders of consciousness.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2045-2322
dc.sourcenlmid: 101563288
dc.titleReorganisation of Brain Hubs across Altered States of Consciousness.
dc.typeArticle
dc.date.updated2020-03-29T01:24:21Z
prism.issueIdentifier1
prism.publicationNameScientific reports
prism.volume10
dc.identifier.doi10.17863/CAM.50956
rioxxterms.versionofrecord10.1038/s41598-020-60258-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidVatansever, D [0000-0002-2494-9945]
dc.contributor.orcidAdapa, R M [0000-0002-9845-8532]
dc.contributor.orcidBullmore, E T [0000-0002-8955-8283]
dc.contributor.orcidStamatakis, E A [0000-0001-6955-9601]
pubs.funder-project-idDepartment of Health (NIHR200256)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International