Patient's clinical presentation and CPPopt availability: any association?
CENTER-TBI High Resolution Sub- Study Participants and Investigators,
Acta Neurochirurgica: Supplementum
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Liberti, A., Beqiri, E., Ercole, A., Cabeleira, M., Tas, J., Zeiler, F., Czosnyka, M., et al. Patient's clinical presentation and CPPopt availability: any association?. Acta Neurochirurgica: Supplementum https://doi.org/10.17863/CAM.51553
Background. The ‘optimal’ CPP (CPPopt) concept is based on the vascular pressure reactivity index called PRx. The feasibility and effectiveness of CPPopt guided therapy in severe traumatic brain injury (TBI) patients is currently being investigated prospectively in the COGiTATE trial. At the moment there is no clear evidence that certain admission and treatment characteristics are associated with CPPopt availability (yield). Objective. To test the relation between patients' admission and treatment characteristics and the average CPPopt yield. Methods. Retrospective analysis of 230 patients from the CENTER-TBI high Resolution database with ICP measured using intraparenchymal probe. CPPopt was calculated using the algorithm set for COGiTATE study. CPPopt yield was defined as the percentage of CPP monitored time (%) when CPPopt is available. Variables in the statistical model were: age, admission GCS, gender, pupil response, hypoxia and hypotension at the scene, Marshall CT score, decom-pressive craniectomy, ISS score and 24-hr TIL score. Results. The median CPPopt yield was 80.7% (IQR 70.9-87.4%). None of the selected variables showed a significant statistical correlation with the CPPopt yield. Conclusion. In this retrospective multicenter study none of the selected admission and treatment variables were related to the CPPopt yield.
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This record's DOI: https://doi.org/10.17863/CAM.51553
This record's URL: https://www.repository.cam.ac.uk/handle/1810/304474
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