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dc.contributor.authorPiedrafita, Gabriel
dc.contributor.authorKostiou, Vasiliki
dc.contributor.authorWabik, Agnieszka
dc.contributor.authorColom, Bartomeu
dc.contributor.authorFernandez-Antoran, David
dc.contributor.authorHerms, Albert
dc.contributor.authorMurai, Kasumi
dc.contributor.authorHall, Benjamin A
dc.contributor.authorJones, Philip H
dc.date.accessioned2020-04-20T01:08:22Z
dc.date.available2020-04-20T01:08:22Z
dc.date.issued2020-03-18
dc.identifier.issn2041-1723
dc.identifier.otherPMC7080751
dc.identifier.other32188860
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/304528
dc.description.abstractIn adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additional transgenic assay to follow cell division in mouse esophagus and the epidermis at multiple body sites. We find that proliferating cells divide at a similar rate, and place bounds on the distribution cell cycle times. By including these results in a common analytic approach, we show that data from eight lineage tracing experiments is consistent with tissue maintenance by a single population of proliferating cells. The outcome of a given cell division is unpredictable but, on average, the likelihood of producing proliferating and differentiating cells is equal, ensuring cellular homeostasis. These findings are key to understanding squamous epithelial homeostasis and carcinogenesis.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleA single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice.
dc.typeArticle
dc.date.updated2020-04-20T01:08:22Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume11
dc.identifier.doi10.17863/CAM.51609
rioxxterms.versionofrecord10.1038/s41467-020-15258-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPiedrafita, Gabriel [0000-0001-8701-1084]
dc.contributor.orcidColom, Bartomeu [0000-0001-6256-6462]
dc.contributor.orcidHall, Benjamin A [0000-0003-0355-2946]
dc.contributor.orcidJones, Philip H [0000-0002-5904-795X]
pubs.funder-project-idRoyal Society (UF130039)
pubs.funder-project-idCancer Research UK (C609/A27326, C/609/A17257)
pubs.funder-project-idWellcome Trust (098051, 296194)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International