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dc.contributor.authorRyyti, Riitta
dc.contributor.authorHämäläinen, Mari
dc.contributor.authorPeltola, Rainer
dc.contributor.authorMoilanen, Eeva
dc.date.accessioned2020-05-08T03:13:11Z
dc.date.available2020-05-08T03:13:11Z
dc.date.issued2020-05-07
dc.date.submitted2019-10-04
dc.identifier.otherpone-d-19-27779
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305142
dc.description.abstractObesity is a constantly increasing health problem worldwide. It is associated with a systemic low-grade inflammation, which contributes to the development of metabolic disorders and comorbidities such as type 2 diabetes. Diet has an important role in the prevention of obesity and its adverse health effects; as a part of healthy diet, polyphenol-rich berries, such as lingonberry (Vaccinium vitis-idaea L.) have been proposed to have health-promoting effects. In the present study, we investigated the effects of lingonberry supplementation on high-fat diet induced metabolic and inflammatory changes in a mouse model of obesity. Thirty male C57BL/6N mice were divided into three groups (n = 10/group) to receive low-fat (LF), high-fat (HF) and lingonberry-supplemented high-fat (HF+LGB) diet for six weeks. Low-fat and high-fat diet contained 10% and 46% of energy from fat, respectively. Lingonberry supplementation prevented the high-fat diet induced adverse changes in blood cholesterol and glucose levels and had a moderate effect on the weight and visceral fat gain, which were 26% and 25% lower, respectively, in the lingonberry group than in the high-fat diet control group. Interestingly, lingonberry supplementation also restrained the high-fat diet induced increases in the circulating levels of the proinflammatory adipocytokine leptin (by 36%) and the inflammatory acute phase reactant serum amyloid A (SAA; by 85%). Similar beneficial effects were discovered in the hepatic expression of the inflammatory factors CXCL-14, S100A10 and SAA by lingonberry supplementation. In conclusion, the present results indicate that lingonberry supplementation significantly prevents high-fat diet induced metabolic and inflammatory changes in a murine model of obesity. The results encourage evaluation of lingonberries as a part of healthy diet against obesity and its comorbidities.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectResearch and analysis methods
dc.titleBeneficial effects of lingonberry ( Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity
dc.typeArticle
dc.date.updated2020-05-08T03:13:11Z
prism.issueIdentifier5
prism.publicationNamePLOS ONE
prism.volume15
dc.identifier.doi10.17863/CAM.52224
dcterms.dateAccepted2020-04-18
rioxxterms.versionofrecord10.1371/journal.pone.0232605
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Vacca, Michele
dc.contributor.orcidRyyti, Riitta [0000-0003-2428-6608]
dc.contributor.orcidMoilanen, Eeva [0000-0002-8577-0316]
dc.identifier.eissn1932-6203


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)