The Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
Global spine journal
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Smith, S. S., Stewart, M. E., Davies, B., & Kotter, M. (2021). The Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.. Global spine journal, 11 (4), 597-607. https://doi.org/10.1177/2192568220934496
Study design: Systematic review and meta-analysis Objectives: Cervical spinal cord compression (SCC) due to degenerative changes of the spine is a frequent finding on MRI. Whilst most people remain asymptomatic, a proportion develop symptoms of degenerative cervical myelopathy (DCM). DCM is an often progressive neurological disease that can cause quadriplegia. The epidemiology of SCC and DCM is poorly understood. We sought to estimate the prevalence of degenerative cervical SCC and DCM from cross-sectional cohorts undergoing MRI. Methods: We conducted a systematic review and meta-analysis of MRI reports on human subjects over sixteen years of age with degenerative SCC. A pre-determined search strategy was used to identify relevant literature on MEDLINE. Title and abstract screening was followed by full text screening. Data was extracted and analysed by fixed or random effects-models. Results: The present search returned 1506 publications. Following our exclusion criteria, nineteen studies were included. Subgroup analysis of 3786 individuals estimated the prevalence of asymptomatic SCC in a healthy population as 24.2% with a significantly higher prevalence of SCC in older populations compared to younger populations and American/European populations compared to Asian populations. Subgroup analysis of 1202 individuals estimated the prevalence of DCM in a healthy population as 2.3%. Conclusions: We present the first estimates of the prevalence of asymptomatic SCC and DCM. Studies investigating the epidemiology of SCC are heterogeneous in methodology and results. These data indicate the need for more studies into the epidemiology of SCC and DCM performed with consistent methodologies.
Department of Health (via National Institute for Health Research (NIHR)) (CS-2015-15-023)
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External DOI: https://doi.org/10.1177/2192568220934496
This record's URL: https://www.repository.cam.ac.uk/handle/1810/305369
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