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dc.contributor.authorGuirado, Ramon
dc.contributor.authorPerez-Rando, Marta
dc.contributor.authorFerragud, Antonio
dc.contributor.authorGutierrez-Castellanos, Nicolas
dc.contributor.authorUmemori, Juzoh
dc.contributor.authorCarceller, Hector
dc.contributor.authorNacher, Juan
dc.contributor.authorCastillo-Gómez, Esther
dc.date.accessioned2020-05-24T00:18:47Z
dc.date.available2020-05-24T00:18:47Z
dc.date.issued2020-04-07
dc.identifier.issn1662-5153
dc.identifier.otherPMC7155216
dc.identifier.other32317945
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305726
dc.description.abstractThe medial prefrontal cortex (mPFC) has been classically defined as the brain region responsible for higher cognitive functions, including the decision-making process. Ample information has been gathered during the last 40 years in an attempt to understand how it works. We now know extensively about the connectivity of this region and its relationship with neuromodulatory ascending projection areas, such as the dorsal raphe nucleus (DRN) or the ventral tegmental area (VTA). Both areas are well-known regulators of the reward-based decision-making process and hence likely to be involved in processes like evidence integration, impulsivity or addiction biology, but also in helping us to predict the valence of our future actions: i.e., what is "good" and what is "bad." Here we propose a hypothesis of a critical period, during which the inputs of the mPFC compete for target innervation, establishing specific prefrontal network configurations in the adult brain. We discuss how these different prefrontal configurations are linked to brain diseases such as addiction or neuropsychiatric disorders, and especially how drug abuse and other events during early life stages might lead to the formation of more vulnerable prefrontal network configurations. Finally, we show different promising pharmacological approaches that, when combined with the appropriate stimuli, will be able to re-establish these functional prefrontocortical configurations during adulthood.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101477952
dc.sourceessn: 1662-5153
dc.subjectCritical period
dc.subjectdecision-making
dc.subjectBasolateral Amygdala
dc.subjectVentral Hippocampus
dc.subjectPrefrontal Networks
dc.titleA Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction.
dc.typeArticle
dc.date.updated2020-05-24T00:18:47Z
prism.publicationNameFrontiers in behavioral neuroscience
prism.volume14
dc.identifier.doi10.17863/CAM.52804
rioxxterms.versionofrecord10.3389/fnbeh.2020.00051
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFerragud, Antonio [0000-0002-6739-007X]
pubs.funder-project-idEuropean Research Council (322742)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International