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dc.contributor.authorPark, Jong-Eun
dc.contributor.authorJardine, Laura
dc.contributor.authorGottgens, Berthold
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorHaniffa, Muzlifah
dc.date.accessioned2020-05-27T13:24:24Z
dc.date.available2020-05-27T13:24:24Z
dc.date.issued2020-05-08
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305816
dc.description.abstractThe blood and immune systems develop in parallel during early prenatal life. Waves of hematopoiesis separated in anatomical space and time give rise to circulating and tissue-resident immune cells. Previous observations have relied on animal models, which differ from humans in both their developmental timeline and exposure to microorganisms. Decoding the composition of the human immune system is now tractable using single-cell multi-omics approaches. Large-scale single-cell genomics, imaging technologies, and the Human Cell Atlas initiative have together enabled a systems-level mapping of the developing human immune system and its emergent properties. Although the precise roles of specific immune cells during development require further investigation, the system as a whole displays malleable and responsive properties according to developmental need and environmental challenge.
dc.description.sponsorshipWellcome Trust, MRC, ERC, NIHR
dc.format.mediumPrint
dc.languageeng
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.subjectLiver
dc.subjectYolk Sac
dc.subjectImmune System
dc.subjectBone Marrow
dc.subjectAnimals
dc.subjectHumans
dc.subjectModels, Animal
dc.subjectGenomics
dc.subjectHematopoiesis
dc.subjectImmunity
dc.subjectSingle-Cell Analysis
dc.titlePrenatal development of human immunity.
dc.typeArticle
prism.endingPage603
prism.issueIdentifier6491
prism.publicationDate2020
prism.publicationNameScience
prism.startingPage600
prism.volume368
dc.identifier.doi10.17863/CAM.52896
dcterms.dateAccepted2020-04-10
rioxxterms.versionofrecord10.1126/science.aaz9330
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-05
dc.contributor.orcidPark, Jong-Eun [0000-0002-1687-2423]
dc.contributor.orcidJardine, Laura [0000-0003-4495-8205]
dc.contributor.orcidGottgens, Berthold [0000-0001-6302-5705]
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.contributor.orcidHaniffa, Muzlifah [0000-0002-3927-2084]
dc.identifier.eissn1095-9203
dc.publisher.urlhttps://science.sciencemag.org/content/368/6491/600/tab-article-info
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (206328/Z/17/Z)
pubs.funder-project-idWellcome Trust (203151/Z/16/Z)
pubs.funder-project-idMedical Research Council (MC_PC_12009)
pubs.funder-project-idMedical Research Council (MC_PC_17230)
cam.issuedOnline2020-05-08


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