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dc.contributor.authorO'Dea, Mary
dc.contributor.authorSweetman, Deirdre
dc.contributor.authorBonifacio, Sonia Lomeli
dc.contributor.authorEl-Dib, Mohamed
dc.contributor.authorAustin, Topun
dc.contributor.authorMolloy, Eleanor J.
dc.date.accessioned2020-05-29T15:05:54Z
dc.date.available2020-05-29T15:05:54Z
dc.date.issued2020-05-15
dc.date.submitted2019-08-17
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305879
dc.description.abstractNeonatal Encephalopathy (NE) describes neonates with disturbed neurological function in the first post-natal days of life. NE is an overall term that does not specify the etiology of the encephalopathy although it often involves hypoxia-ischaemia. In NE, although neurological dysfunction is part of the injury and is most predictive of long-term outcome, these infants may also have multiorgan injury and compromise, which further contribute to neurological impairment and long-term morbidities. Therapeutic hypothermia (TH) is the standard of care for moderate to severe NE. Infants with NE may have co-existing immune, respiratory, endocrine, renal, hepatic, and cardiac dysfunction that require individualized management and can be impacted by TH. Non-neurological organ dysfunction not only has a negative effect on long term outcome but may also influence the efficacy of treatments in the acute phase. Post resuscitative care involves stabilization and decisions regarding TH and management of multi-organ dysfunction. This management includes detailed neurological assessment, cardio-respiratory stabilization, glycaemic and fluid control, sepsis evaluation and antibiotics, seizure identification, and monitoring and responding to biochemical and coagulation derangements. The emergence of new biomarkers of specific organ injury may have predictive value and improve the definition of organ injury and prognosis. Further evidence-based research is needed to optimize management of NE, prevent further organ dysfunction and reduce neurodevelopmental impairment.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPediatrics
dc.subjectNeonatal Encephalopathy
dc.subjectTherapeutic hypothermia
dc.subjectbrain injury
dc.subjectmulti-organ dysfunction
dc.subjectneurodevelopmental outcome
dc.titleManagement of Multi Organ Dysfunction in Neonatal Encephalopathy
dc.typeArticle
dc.date.updated2020-05-29T15:05:54Z
prism.publicationNameFrontiers in Pediatrics
prism.volume8
dc.identifier.doi10.17863/CAM.52960
dcterms.dateAccepted2020-04-20
rioxxterms.versionofrecord10.3389/fped.2020.00239
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-2360


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)