Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
dc.contributor.author | Tay, Jonathan | |
dc.contributor.author | Morris, Robin G | |
dc.contributor.author | Tuladhar, Anil M | |
dc.contributor.author | Husain, Masud | |
dc.contributor.author | de Leeuw, Frank-Erik | |
dc.contributor.author | Markus, Hugh S | |
dc.date.accessioned | 2020-07-14T07:09:23Z | |
dc.date.available | 2020-07-14T07:09:23Z | |
dc.date.issued | 2020-07-10 | |
dc.date.submitted | 2020-02-24 | |
dc.identifier.citation | Journal of Neurology, Neurosurgery, and Psychiatry, page jnnp-2020-323092 | |
dc.identifier.issn | 0022-3050 | |
dc.identifier.other | jnnp-2020-323092 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/307912 | |
dc.description.abstract | Objective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in a subset of 104 participants with longitudinal data from SCANS. All models were controlled for age, education and cognitive function. Results: Baseline apathy scores predicted dementia in SCANS (HR 1.49, 95% CI 1.05 to 2.11, p=0.024) and RUN DMC (HR 1.05, 95% CI 1.01 to 1.09, p=0.007). Increasing apathy was associated with dementia in SCANS (HR 1.53, 95% CI 1.08 to 2.17, p=0.017). In contrast, baseline depression and change in depression did not predict dementia in either dataset. Including apathy in predictive models of dementia improved model fit. Conclusions: Apathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful in identifying at-risk individuals. | |
dc.language | en | |
dc.publisher | BMJ Publishing Group | |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Neuropsychiatry | |
dc.subject | 1506 | |
dc.title | Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease | |
dc.type | Article | |
dc.date.updated | 2020-07-14T07:09:23Z | |
dc.embargo.terms | Embargo: ends 2020-07-10 | en |
dc.identifier.doi | 10.17863/CAM.55005 | |
dcterms.dateAccepted | 2020-06-02 | |
rioxxterms.versionofrecord | 10.1136/jnnp-2020-323092 | |
rioxxterms.version | VoR | |
dc.contributor.orcid | Tay, Jonathan [0000-0003-0598-0004] | |
dc.contributor.orcid | Tuladhar, Anil M [0000-0002-4815-2834] | |
dc.identifier.eissn | 1468-330X | |
pubs.funder-project-id | The Stroke Association (TSA PPA 2015-02) | |
pubs.funder-project-id | National Institute for Health Research (146281) | |
pubs.funder-project-id | Hartstichting (2014T060, 2016T044) | |
pubs.funder-project-id | ZonMw (ZonMW 016-126-351) | |
pubs.funder-project-id | Wellcome Trust (098282) | |
rioxxterms.freetoread.startdate | 2020-07-10 |
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