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dc.contributor.authorChristodoulou, Neophytos
dc.contributor.authorWeberling, Antonia
dc.contributor.authorStrathdee, Douglas
dc.contributor.authorAnderson, Kurt I.
dc.contributor.authorTimpson, Paul
dc.contributor.authorZernicka-Goetz, Magdalena
dc.date.accessioned2020-08-06T16:14:17Z
dc.date.available2020-08-06T16:14:17Z
dc.date.issued2019-08-07
dc.date.submitted2019-02-08
dc.identifier.others41467-019-11482-5
dc.identifier.other11482
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308850
dc.description.abstractAbstract: Mammalian embryos change shape dramatically upon implantation. The cellular and molecular mechanism underlying this transition are largely unknown. Here, we show that this transition is directed by cross talk between the embryonic epiblast and the first extra-embryonic tissue, the trophectoderm. Specifically, we show via visualisation of a Cdx2-GFP reporter line and pharmacologically mediated loss and gain of function experiments that the epiblast provides FGF signal that results in differential fate acquisition in the multipotent trophectoderm leading to the formation of a tissue boundary within this tissue. The trophectoderm boundary becomes essential for expansion of the tissue into a multi-layered epithelium. Folding of this multi-layered trophectoderm induces spreading of the second extra-embryonic tissue, the primitive endoderm. Together, these events remodel the pre-implantation embryo into its post-implantation cylindrical shape. Our findings uncover how communication between embryonic and extra-embryonic tissues provides positional cues to drive shape changes in mammalian development during implantation.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/136/2086
dc.subject/631/136/1660
dc.subject/14/19
dc.subject/64/60
dc.subject/14/1
dc.subject/13/1
dc.subjectarticle
dc.titleMorphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
dc.typeArticle
dc.date.updated2020-08-06T16:14:16Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume10
dc.identifier.doi10.17863/CAM.55938
dcterms.dateAccepted2019-07-03
rioxxterms.versionofrecord10.1038/s41467-019-11482-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidChristodoulou, Neophytos [0000-0003-4338-5847]
dc.contributor.orcidStrathdee, Douglas [0000-0003-2959-4327]
dc.contributor.orcidAnderson, Kurt I. [0000-0002-9324-9598]
dc.contributor.orcidZernicka-Goetz, Magdalena [0000-0002-7004-2471]
dc.identifier.eissn2041-1723


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