The productive use of toxic waste materials derived from industrial processes is one of the main goals of the modern chemical research to increase the sustainability of the large scale production. Here we devise a simple and robust strategy for the utilization of trifluoromethane, obtained in large quantities from Teflon manufacture, and the conversion of this greenhouse gas into valuable perfluorinated compounds. The generation of the trifluoromethyl carbanion and its direct and complete consumption through trapping with a number of electrophiles were achieved by a fully contained flow reactor setup. The adoption of modern in-line analytical tools, such as portable FT-IR and NMR devices, allowed the accurate reagent dosage with considerable benefits in terms of controlling the environmental impact during this continuous process. The advantages of the method, with respect to the batch procedure, will be discussed and demonstrated experimentally.