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dc.contributor.authorBurgess, Stephenen
dc.contributor.authorDavey Smith, Georgeen
dc.contributor.authorDavies, Neilen
dc.contributor.authorDudbridge, Franken
dc.contributor.authorGill, Dipenderen
dc.contributor.authorGlymour, Mariaen
dc.contributor.authorHartwig, Fernandoen
dc.contributor.authorHolmes, Michaelen
dc.contributor.authorMinelli, Cosettaen
dc.contributor.authorRelton, Carolineen
dc.contributor.authorTheodoratou, Evropien
dc.date.accessioned2020-08-20T08:18:52Z
dc.date.available2020-08-20T08:18:52Z
dc.identifier.issn2398-502X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309427
dc.description.abstractThis paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
dc.language.isoenen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGuidelines for performing Mendelian randomization investigationsen
dc.typeArticle
prism.number186en
prism.publicationNameWellcome Open Researchen
prism.volume4en
dc.identifier.doi10.17863/CAM.56516
dcterms.dateAccepted2020-04-28en
rioxxterms.versionofrecord10.12688/wellcomeopenres.15555.2en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-04-28en
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.identifier.eissn2398-502X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
cam.issuedOnline2020-04-28en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International