Robustness to misalignment of low-cost, compact quantitative phase imaging architectures.
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Authors
Wilson, Abby
Publication Date
2020-10-15Journal Title
OSA Contin
ISSN
2578-7519
Publisher
The Optical Society
Volume
3
Issue
10
Pages
2660-2679
Language
eng
Type
Article
This Version
AM
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Fitzpatrick, C., Wilson, A., Sawyer, T. W., Christopher, P. J., Wilkinson, T., Bohndiek, S., & Gordon, G. (2020). Robustness to misalignment of low-cost, compact quantitative phase imaging architectures.. OSA Contin, 3 (10), 2660-2679. https://doi.org/10.1364/OSAC.395498
Abstract
Non-interferometric approaches to quantitative phase imaging could enable its application in low-cost, miniaturised settings such as capsule endoscopy. We present two possible architectures and both analyse and mitigate the effect of sensor misalignment on phase imaging performance. This is a crucial step towards determining the feasibility of implementing phase imaging in a capsule device. First, we investigate a design based on a folded 4f correlator, both in simulation and experimentally. We demonstrate a novel technique for identifying and compensating for axial misalignment and explore the limits of the approach. Next, we explore the implications of axial and transverse misalignment, and of manufacturing variations on the performance of a phase plate-based architecture, identifying a clear trade-off between phase plate resolution and algorithm convergence time. We conclude that while the phase plate architecture is more robust to misalignment, both architectures merit further development with the goal of realising a low-cost, compact system for applying phase imaging in capsule endoscopy.
Relationships
Is supplemented by: https://doi.org/10.17863/CAM.56831
Sponsorship
Cancer Research Uk (None)
Cancer Research UK (C14303/A17197)
Cancer Research UK (21102)
Cancer Research UK (24669)
Cancer Research UK (C20/A20976)
Identifiers
External DOI: https://doi.org/10.1364/OSAC.395498
This record's URL: https://www.repository.cam.ac.uk/handle/1810/309619
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