jats:p While scholars have highlighted how science communication reifies forms of structural inequality, especially race and gender, we examine the challenges science communication pose for religious minorities. Drawing on the disproportionate magnitude of COVID-19-related morbidity on Israel’s Ultra-Orthodox Jews, we examined their processes of COVID-19 health decision making. Survey results show that both religious and health-related justifications were common for personal decisions, yet a disparity was found between the ways social distancing guidelines were perceived in the general education context compared with the religious context, signaling the importance for inclusive models of science communication that account for religious sensibilities and state-minority relations. </jats:p>