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dc.contributor.authorMoutchia, Jude
dc.contributor.authorPokharel, Pratik
dc.contributor.authorKerri, Aldiona
dc.contributor.authorMcGaw, Kaodi
dc.contributor.authorUchai, Shreeshti
dc.contributor.authorNji, Miriam
dc.contributor.authorGoodman, Michael
dc.date.accessioned2020-10-02T01:12:29Z
dc.date.available2020-10-02T01:12:29Z
dc.date.issued2020-10-01
dc.date.submitted2020-08-04
dc.identifier.otherpone-d-20-24329
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/310987
dc.descriptionFunder: Bamenda Regional Hospital
dc.description.abstractBackground: To date, several clinical laboratory parameters associated with Coronavirus disease 2019 (COVID-19) severity have been reported. However, these parameters have not been observed consistently across studies. The aim of this review was to assess clinical laboratory parameters which may serve as markers or predictors of severe or critical COVID-19. Methods and findings: We conducted a systematic search of MEDLINE, Embase, Web of Science, CINAHL and Google Scholar databases from 2019 through April 18, 2020, and reviewed bibliographies of eligible studies, relevant systematic reviews, and the medRxiv pre-print server. We included hospital-based observational studies reporting clinical laboratory parameters of confirmed cases of COVID-19 and excluded studies having large proportions (>10%) of children and pregnant women. Two authors independently carried out screening of articles, data extraction and quality assessment. Meta-analyses were done using random effects model. Meta-median difference (MMD) and 95% confidence interval (CI) was calculated for each laboratory parameter. Forty-five studies in 6 countries were included. Compared to non-severe COVID-19 cases, severe or critical COVID-19 was characterised by higher neutrophil count (MMD: 1.23 [95% CI: 0.58 to 1.88] ×109 cells/L), and lower lymphocyte, CD4 and CD8 T cell counts with MMD (95% CI) of -0.39 (-0.47, -0.31) ×109 cells/L, -204.9 (-302.6, -107.1) cells/μl and -123.6 (-170.6, -76.6) cells/μl, respectively. Other notable results were observed for C-reactive protein (MMD: 36.97 [95% CI: 27.58, 46.35] mg/L), interleukin-6 (MMD: 17.37 [95% CI: 4.74, 30.00] pg/ml), Troponin I (MMD: 0.01 [0.00, 0.02] ng/ml), and D-dimer (MMD: 0.65 [0.45, 0.85] mg/ml). Conclusions: Relative to non-severe COVID-19, severe or critical COVID-19 is characterised by increased markers of innate immune response, decreased markers of adaptive immune response, and increased markers of tissue damage and major organ failure. These markers could be used to recognise severe or critical disease and to monitor clinical course of COVID-19.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectMedicine and health sciences
dc.subjectResearch and analysis methods
dc.subjectPhysical sciences
dc.subjectBiology and life sciences
dc.titleClinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
dc.typeArticle
dc.date.updated2020-10-02T01:12:28Z
prism.issueIdentifier10
prism.publicationNamePLOS ONE
prism.volume15
dc.identifier.doi10.17863/CAM.58075
dcterms.dateAccepted2020-09-09
rioxxterms.versionofrecord10.1371/journal.pone.0239802
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Simonin, Anna
dc.contributor.orcidMoutchia, Jude [0000-0002-4892-9471]
dc.identifier.eissn1932-6203


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)