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dc.contributor.authorZhang, Xiayin
dc.contributor.authorXiao, Hui
dc.contributor.authorLiu, Chunxin
dc.contributor.authorLiu, Sanxin
dc.contributor.authorZhao, Lanqin
dc.contributor.authorWang, Ruixin
dc.contributor.authorWang, Jinghui
dc.contributor.authorWang, Ting
dc.contributor.authorZhu, Yi
dc.contributor.authorChen, Chuan
dc.contributor.authorWu, Xiaohang
dc.contributor.authorLin, Duoru
dc.contributor.authorQiu, Wei
dc.contributor.authorYu-Wai-Man, Patrick
dc.contributor.authorLu, Zhengqi
dc.contributor.authorLin, Haotian
dc.description.abstractCerebrovascular disease (CeVD) is one of the leading global causes of death and severe disability. To date, retinal microangiopathy has become a reflection of cerebral microangiopathy, mirroring the vascular pathological modifications in vivo. To evaluate the retinal structure and microvasculature in patients with CeVD, we conducted a cross-sectional study in Zhongshan Ophthalmic Center and Department of Neurology of Third Affiliated Hospital, Sun Yat-sen University using optical coherence tomography angiography (OCTA). CeVD patients (n = 121; 238 eyes) and healthy controls (n = 44; 57 eyes) were included in the analysis. The CeVD group showed significant thinning of the peripapillary retinal nerve fiber layer (pRNFL) thickness in the temporal and nasal quadrants, and thinning of the macular ganglion cell-inner plexiform layer (GC-IPL) in the inferior quadrant, while macular microvasculature reduction was prominent in all nine quadrants. There were significant correlations between OCTA parameters, visual acuity, and transcranial doppler parameters in the CeVD group. The specific structural parameters combining microvasculature indices showed the best diagnostic accuracies (AUC = 0.918) to discriminate CeVD group from healthy controls. To conclude, we proved that OCTA reveals specific patterns of retinal structural changes and extensive macular microvascular changes in CeVD. Additionally, these retinal abnormalities could prove useful disease biomarkers in the management of individuals at high risk of debilitating complications from a cerebrovascular event.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.subjectcerebrovascular disease
dc.subjectoptical coherence tomography angiography
dc.subjectretinal vascular density
dc.subjectretinal structure
dc.subjectretinal microvasculature
dc.titleOptical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease
prism.publicationNameFrontiers in Neuroscience

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)