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dc.contributor.authorPan, Jia-Wernen
dc.contributor.authorZabidi, Muhammad Mamduh Ahmaden
dc.contributor.authorNg, Pei-Szeen
dc.contributor.authorMeng, Mei-Yeeen
dc.contributor.authorHasan, Siti Norhidayuen
dc.contributor.authorSandey, Bethanen
dc.contributor.authorSammut, Stephenen
dc.contributor.authorYip, Cheng-Haren
dc.contributor.authorRajadurai, Pathmanathanen
dc.contributor.authorRueda Palacio, Oscaren
dc.contributor.authorCaldas, Carlosen
dc.contributor.authorChin, Suet-Feungen
dc.contributor.authorTeo, Soo-Hwangen
dc.date.accessioned2020-11-03T00:31:04Z
dc.date.available2020-11-03T00:31:04Z
dc.date.issued2020-12-22en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312348
dc.description.abstractMolecular profiles of breast cancer have contributed to an improved understanding of the disease, enabled development of molecular prognostic signatures to guide treatment decisions and unveiled new or more accurate therapeutic options for breast cancer patients. However, the extent to which differences in genetic, environmental and lifestyle factors influence molecular profiles in different populations remains poorly characterised, as relatively few large-scale molecular studies of breast tumours in non-Caucasian populations have hitherto been reported. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to the breast tumours in predominantly Caucasian women reported in TCGA and METABRIC, we show an increased prevalence of Her2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. Using gene expression and immunohistochemistry, we observed elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst Her2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil new opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.
dc.description.sponsorshipScientex Foundation, Estée Lauder Companies, Yayasan Petronas, and Yayasan Sime Darby
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rightsAttribution 4.0 International
dc.rights.uri
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumansen
dc.subjectBreast Neoplasmsen
dc.subjectReceptor, erbB-2en
dc.subjectReceptors, Estrogenen
dc.subjectSurvival Analysisen
dc.subjectGenetics, Populationen
dc.subjectMutationen
dc.subjectGenome, Humanen
dc.subjectAsian Continental Ancestry Groupen
dc.subjectEuropean Continental Ancestry Groupen
dc.subjectFemaleen
dc.subjectTumor Suppressor Protein p53en
dc.subjectTumor Microenvironmenten
dc.titleThe molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameNature communicationsen
prism.startingPage6433
prism.volume11en
dc.identifier.doi10.17863/CAM.59440
dcterms.dateAccepted2020-11-17en
rioxxterms.versionofrecord10.1038/s41467-020-20173-5en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-12-22en
dc.contributor.orcidSandey, Bethan [0000-0001-9448-8673]
dc.contributor.orcidSammut, Stephen [0000-0003-4472-904X]
dc.contributor.orcidYip, Cheng-Har [0000-0002-6507-9675]
dc.contributor.orcidRueda, Oscar [0000-0003-0008-4884]
dc.contributor.orcidCaldas, Carlos [0000-0003-3547-1489]
dc.contributor.orcidChin, Suet [0000-0001-5697-1082]
dc.contributor.orcidTeo, Soo-Hwang [0000-0002-0444-590X]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (CB4140)
pubs.funder-project-idMRC (MR/P012442/1)
pubs.funder-project-idWELLCOME TRUST (106566/Z/14/Z)
pubs.funder-project-idCancer Research UK (CRUK-A16942)
cam.orpheus.successMon Feb 08 07:31:57 GMT 2021 - The item has an open VoR version.*
cam.orpheus.counter13*
rioxxterms.freetoread.startdate2100-01-01


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