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dc.contributor.authorSinha, Sanjay
dc.contributor.authorIyer, Dharini
dc.contributor.authorGranata, Alessandra
dc.date.accessioned2020-11-10T13:34:23Z
dc.date.available2020-11-10T13:34:23Z
dc.date.issued2014-06
dc.identifier.issn1420-682X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312716
dc.description.abstractVascular smooth muscle cells (SMCs) arise from multiple origins during development, raising the possibility that differences in embryological origins between SMCs could contribute to site-specific localization of vascular diseases. In this review, we first examine the developmental pathways and embryological origins of vascular SMCs and then discuss in vitro strategies for deriving SMCs from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We then review in detail the potential for vascular disease modeling using iPSC-derived SMCs and consider the pathological implications of heterogeneous embryonic origins. Finally, we touch upon the role of human ESC-derived SMCs in therapeutic revascularization and the challenges remaining before regenerative medicine using ESC- or iPSC-derived cells comes of age.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectMuscle, Smooth, Vascular
dc.subjectCells, Cultured
dc.subjectMyocytes, Smooth Muscle
dc.subjectAnimals
dc.subjectHumans
dc.subjectRegenerative Medicine
dc.subjectCell Differentiation
dc.subjectModels, Biological
dc.subjectEmbryonic Stem Cells
dc.titleEmbryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application.
dc.typeArticle
prism.endingPage2288
prism.issueIdentifier12
prism.publicationDate2014
prism.publicationNameCell Mol Life Sci
prism.startingPage2271
prism.volume71
dc.identifier.doi10.17863/CAM.59812
dcterms.dateAccepted2013-12-30
rioxxterms.versionofrecord10.1007/s00018-013-1554-3
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-06
dc.contributor.orcidSinha, Sanjay [0000-0001-5900-1209]
dc.contributor.orcidGranata, Alessandra [0000-0001-5051-8201]
dc.identifier.eissn1420-9071
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (G1000847)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (G0800784)
cam.issuedOnline2014-01-18
datacite.issourceof.doi10.1038/ng.3723
datacite.issourceof.doi10.1089/scd.2014.0520
rioxxterms.freetoread.startdate2015-06-30


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