Placental energy metabolism in health and disease-significance of development and implications for preeclampsia.
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Publication Date
2020-11-13Journal Title
American journal of obstetrics and gynecology
ISSN
0002-9378
Publisher
Elsevier BV
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Aye, I., Aiken, C., Charnock-Jones, S., & Smith, G. (2020). Placental energy metabolism in health and disease-significance of development and implications for preeclampsia.. American journal of obstetrics and gynecology https://doi.org/10.1016/j.ajog.2020.11.005
Abstract
The placenta is a highly metabolically active organ fulfilling the bioenergetic and biosynthetic needs to support its own rapid growth and that of the fetus. Placental metabolic dysfunction is a common occurrence in preeclampsia although its causal relationship to the pathophysiology is unclear. At the outset, this may simply be seen as an “engine out of fuel”. However, placental metabolism plays a vital role beyond energy production and is linked to physiological and developmental processes. In this review, we discuss the metabolic basis for placental dysfunction and propose that the alterations in energy metabolism may explain many of the placental phenotypes of preeclampsia such as reduced placental and fetal growth, redox imbalance, oxidative stress, altered epigenetic and gene expression profiles, and the functional consequences of these aberrations. We propose that placental metabolic reprogramming reflects the dynamic physiological state allowing the tissue to adapt to developmental changes and respond to preeclampsia stress whereas, the inability to reprogram placental metabolism may result in severe preeclampsia phenotypes. Lastly, we discuss common tested and novel therapeutic strategies for treating placental dysfunction in preeclampsia and their impact on placental energy metabolism as possible explanations into their potential benefits or harm.
Sponsorship
I.L.M.H. Aye is funded by a Next Generation Fellowship from the Centre for
20 Trophoblast Research, University of Cambridge
Embargo Lift Date
2021-11-30
Identifiers
External DOI: https://doi.org/10.1016/j.ajog.2020.11.005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/312960
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/